105643-17-2Relevant academic research and scientific papers
Stereoselective and Site-Specific Allylic Alkylation of Amino Acids and Small Peptides via a Pd/Cu Dual Catalysis
Huo, Xiaohong,He, Rui,Fu, Jingke,Zhang, Jiacheng,Yang, Guoqiang,Zhang, Wanbin
supporting information, p. 9819 - 9822 (2017/08/02)
We report a stereoselective and site-specific allylic alkylation of Schiff base activated amino acids and small peptides via a Pd/Cu dual catalysis. A range of noncoded α,α-dialkyl α-amino acids were easily synthesized in high yields and with excellent enantioselectivities (up to >99% ee). Furthermore, a direct and highly stereoselective synthesis of small peptides with enantiopure α-alkyl or α,α-dialkyl α-amino acids residues incorporated at specific sites was accomplished using this dual catalyst system.
Oxidation by Cobalt(III) Acetate. Part 10. Effects of Ring Substituents on the Product Distributions in the Oxidation of β-Methylstyrenes by Cobalt(III) Acetate in Acetic Acid
Morimoto, Takashi,Hirano, Masao,Echigoya, Kohki,Sato, Takafumi
, p. 1205 - 1210 (2007/10/02)
The oxidation of ring-substituted β-methylstyrenes by cobalt(III) acetate in acetic acid has been studied by product analysis and the relative rates were measured by a competition method.Electron-releasing groups (p-MeO, pMe and p-But) accelerated both the reaction rate and the formation of glycol monoacetates, while electron-withdrawing groups (p-Cl and m-Cl) not only retarded the reaction but also favoured the formation of allylic acetate instead of glycol monoacetate.The good relationship of relative rates with ?+ in the Hammett plot showed that both products were derived from the same intermediate.The reaction mechanism is discussed in connection with the stabilities of radical cations formed by a one-electron transfer from the olefins to cobalt(III) acetate.
