105644-17-5

Basic information

• Product Name: 1-(3,4-Dihydroxyphenyl)-2-[(1,1-dimethylethyl)amino]ethanone
• Synonyms: 1-(3,4-Dihydroxyphenyl)-2-[(1,1-dimethylethyl)amino]ethanone;1-Oxo Colterol
• CAS NO: 105644-17-5
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.26828
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 105644-17-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 199–201°C
• Appearance: /
• Storage Temp.: Hygroscopic, -86°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Air Sensitive
• CAS DataBase Reference: 1-(3,4-Dihydroxyphenyl)-2-[(1,1-dimethylethyl)amino]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-Dihydroxyphenyl)-2-[(1,1-dimethylethyl)amino]ethanone(105644-17-5)
• EPA Substance Registry System: 1-(3,4-Dihydroxyphenyl)-2-[(1,1-dimethylethyl)amino]ethanone(105644-17-5)

Safety Data

• Hazardous Substances Data: 105644-17-5(Hazardous Substances Data)

Usage

Description

1-(3,4-Dihydroxyphenyl)-2-[(1,1-dimethylethyl)amino]ethanone, also known as 1-Oxo Colterol, is a derivative of Colterol (C215850), a β-Adrenergic agonist. It is a beige solid with chemical properties that make it a valuable compound in various applications.

Uses

Used in Pharmaceutical Industry:
1-(3,4-Dihydroxyphenyl)-2-[(1,1-dimethylethyl)amino]ethanone is used as a pharmaceutical compound for its β-Adrenergic agonist properties. As a derivative of Colterol, it plays a role in modulating the adrenergic receptors, which can have various therapeutic applications, particularly in treating conditions related to the cardiovascular and respiratory systems.
Used in Chemical Research:
In the field of chemical research, 1-(3,4-Dihydroxyphenyl)-2-[(1,1-dimethylethyl)amino]ethanone serves as a valuable compound for studying the structure-activity relationships of β-Adrenergic agonists. Its unique chemical structure allows researchers to explore new avenues in drug design and development, potentially leading to the discovery of more effective and safer medications.
Used in Material Science:
The beige solid form of 1-(3,4-Dihydroxyphenyl)-2-[(1,1-dimethylethyl)amino]ethanone may also find applications in material science, where its specific chemical and physical properties can be utilized in the development of new materials or the improvement of existing ones. This could include applications in coatings, adhesives, or other industrial materials where the properties of the compound can be advantageous.

Preparation

Preparation by demethylation of 2-tert-butylamino1-(3,4-dimethoxyphenyl)ethanone hydrochloride with aqueous hydrobromic acid.

Upstream product

• 99-40-1 2-chloro-3',4'-dihydroxyacetophenone 
• 75-64-9 tert-butylamine 
• 56961-48-9 2-chloro-3′,4′-dihydroxyacetophenone 
• 91-16-7 1,2-dimethoxybenzene 

Downstream Products

• 47777-01-5 C₃₀H₃₃NO₅ 
• 47776-99-8 C₃₀H₃₃NO₅ 
• 34715-64-5 3,4-dihydroxyphenyl N-(tert-butyl)aminomethyl ketone hydrochloride 
• 47776-91-0 C₃₀H₃₅NO₅ 
• 47589-79-7 4-Methyl-benzoic acid 2-acetoxy-4-(2-tert-butylamino-acetyl)-phenyl ester 
• 30392-75-7 Decanoic acid 5-(2-tert-butylamino-1-hydroxy-ethyl)-2-decanoyloxy-phenyl ester 
• 47776-98-7 C₃₀H₃₅NO₅ 
• 47888-62-0 Octadecanoic acid 5-(2-tert-butylamino-1-hydroxy-ethyl)-2-octadecanoyloxy-phenyl ester 
• 57540-53-1 3-Methyl-butyric acid 5-(2-tert-butylamino-1-hydroxy-ethyl)-2-(3-methyl-butyryloxy)-phenyl ester 
• 47777-02-6 C₃₀H₃₅NO₅ 
• 47733-20-0 4-Methyl-benzoic acid 2-benzoyloxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-phenyl ester 
• 47733-26-6 4-Methyl-benzoic acid 2-benzoyloxy-5-(2-tert-butylamino-acetyl)-phenyl ester 
• 69837-40-7 3-Methyl-butyric acid 5-(2-tert-butylamino-acetyl)-2-(2,2-dimethyl-propionyloxy)-phenyl ester 
• 47777-03-7 C₃₀H₃₃NO₅ 

Relevant articles and documents

USE OF CATECHOLAMINES AND RELATED COMPOUNDS AS ANTI-ANGIOGENIC AGENTS

A catecholamine or related compound of formula (I) having (S)-configuration at β-carbon and having a lipophilicity greater than (S)- noradrenalme, a physiologically tolerated salt thereof, a prodrug thereof, a physiologically functional derivative thereof or any mixture thereof is useful as an anti-angiogemc agent A catecholamine or related compound of formula (II) in which a β-hydroxy group has been modified is also anti-angiogemc