105644-83-5Relevant academic research and scientific papers
PREPARATION OF 21-METHOXYCARBONYL-21-METHYLENE-5-PREGNEN-3β-OL DERIVATIVES
Pouzar, Vladimir,Karaszova, Lenka,Havel, Miroslav
, p. 2735 - 2743 (2007/10/02)
Reaction of 3β-methoxymethoxy-21-nor-5-pregnen-20-ol p-toluenesulfonate (II) with sodium dimethyl malonate afforded dimethyl 3β-methoxymethoxy-5-pregnene-21,21-dicarboxylate (III).Partial hydrolysis of III, followed by reaction with formaldehyde and diethylamine, gave methyl 3β-methoxymethoxy-21-methylene-5-pregnene-21-carboxylate (XVI) which was further transformed into hemisuccinate XIX.
