117151-39-0

Upstream product

• 105644-83-5 3β-Methoxymethoxy-21-nor-5-pregnen-20-ol p-Toluenesulfonate 
• 105644-78-8 Dimethyl 3β-Methoxymethoxy-5-pregnen-21,21-dicarboxylate 
• 86792-22-5 ethyl 3β-acetoxy-22ζ-cyano-21,24-dinor-5-cholen-23-oate 
• 88128-34-1 (3β,17β)-3-(methoxymethoxy)-androst-5-ene-17-methanol 
• 117151-38-9 Methyl 3β-Hydroxy-5-pregnene-21-carboxylate 
• 117151-36-7 3-((3S,8S,9S,10R,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionic acid 
• 1666-13-3 diphenyl diselenide 
• 105644-77-7 Methyl 3β-Methoxymethoxy-5-pregnen-21-carboxylate 

Relevant academic research and scientific papers

PREPARATION OF 21-METHOXYCARBONYL-21-METHYLENE-5-PREGNEN-3β-OL DERIVATIVES

Reaction of 3β-methoxymethoxy-21-nor-5-pregnen-20-ol p-toluenesulfonate (II) with sodium dimethyl malonate afforded dimethyl 3β-methoxymethoxy-5-pregnene-21,21-dicarboxylate (III).Partial hydrolysis of III, followed by reaction with formaldehyde and diethylamine, gave methyl 3β-methoxymethoxy-21-methylene-5-pregnene-21-carboxylate (XVI) which was further transformed into hemisuccinate XIX.