1056676-15-3

Basic information

• Product Name: (2S,4S,5S)-5-azido-6-benzyloxy-4-hydroxy-2-isopropyl-hexanoic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide
• Synonyms: (2S,4S,5S)-5-azido-6-benzyloxy-4-hydroxy-2-isopropyl-hexanoic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide
• CAS NO: 1056676-15-3
• Molecular Weight: 523.676
• Mol File: 1056676-15-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4S,5S)-5-azido-6-benzyloxy-4-hydroxy-2-isopropyl-hexanoic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S,5S)-5-azido-6-benzyloxy-4-hydroxy-2-isopropyl-hexanoic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide(1056676-15-3)
• EPA Substance Registry System: (2S,4S,5S)-5-azido-6-benzyloxy-4-hydroxy-2-isopropyl-hexanoic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide(1056676-15-3)

Safety Data

• Hazardous Substances Data: 1056676-15-3(Hazardous Substances Data)

Upstream product

• 1000045-28-2 (3S,5S)-5-[(1S)-1-azido-2-benzyloxyethyl]-3-isopropyldihydrofuran-2-one 
• 129253-02-7 (2S,3S)-2-amino-N-benzyl-3-methylpentanamide 
• 1056674-45-3 (3S,5S)-5-((R)-1,2-dihydroxyethyl)-3-isopropyldihydrofuran-2(3H)-one 
• 1056674-54-4 (3S,5S)-5-[(1R)-2-(benzyloxy)-1-hydroxyethyl]-3-isopropyldihydrofuran-2(3H)-one 
• 1056674-35-1 5,6-di-O-benzyl-2,3-dideoxy-D-glucono-1,4-lactone 
• 1056674-18-0 methyl 5,6-di-O-benzyl-3-deoxy-α-D-glucofuranoside 
• 1056674-40-8 (3S,5S)-5-((R)-1,2-bis(benzyloxy)ethyl)-3-isopropyldihydrofuran-2(3H)-one 
• 1056674-30-6 (2S,5S)-2-((R)-1,2-bis(benzyloxy)ethyl)-5-methoxytetrahydrofuran 
• 1056681-24-3 C₁₇H₂₁F₃O₆S 
• 100-39-0 benzyl bromide 
• 112031-55-7 5,6-di-O-benzyl-3-deoxy-1,2-O-isopropylidene-α-D-glucofuranoside 

Relevant articles and documents

NEW COMPOUNDS

The invention provides compounds of the formula I wherein Q is aryl or heterocyclyl any of which is optionally substituted; Z is O, S, NRa or S(=O)p; Y is NH, NHNH, CH2NH, O, S or S(=O)p; n is 0, 1, 2 or 3; m is 0, 1 or 2; p is 1 or 2; Ra is H or C1-C4alkyl; R1 is hydrogen, C1-C6alkyl, C0-C3alkanediylC3-C7cycloalkyl, C0-C3alkanediylaryl or C0- C3alkanediylheterocyclyl; R2 is hydrogen or C1-C6alkyl; X' is hydrogen, fluoro, hydroxy, amino or C1-C6alkoxy; X" is hydrogen, or when X' is fluoro, then X" may also be fluoro; R3is C1-C6alkyl; R4' is C1-C6alkyl; R4" is H or C1-C6alkyl; or R4' and R4" together with the carbon atom to which they are attached define a C3-C6cycloalkyl; W is C1-C6alkyl, C3-C7cycloalkyl, aryl or heterocyclyl any of which is optionally substituted; or a pharmaceutically acceptable salt, hydrate or N-oxide thereof. The compounds of the invention are inhibitors of aspartyl proteases such as renin and are among other things useful for the treatment of conditions associated with activities of the RAS, such as hypertension, heart failure and renal insufficiency.