105676-41-3

Upstream product

• 105676-52-6 2,3,5-trideoxy-3,5-di-C-methyl-D-talo-heptono-1,4-lactone 
• 105676-38-8 3,5-dideoxy-3,5-di-C-methyl-6,7-O-isopropylidene-D-glycero-D-talo-heptono-1,4-lactone 
• 115495-42-6 3-deoxy-3-C-methyl-1-O-(2,4,6-triisopropyl)benzenesulfonyl-D-arabinitol 
• 105676-40-2 3,5-dideoxy-3,5-di-C-methyl-5,6-O-isopropylidene-D-talitol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 115479-70-4 (2S,3S,4R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-2-methyl-pentanal 
• 105676-45-7 3-deoxy-3-tris(methylthio)methyl-5-O-tert-butyldiphenylsilyl-D-arabino-1,4-lactone 
• 115495-41-5 1-O-tert-butyldiphenylsilyl-3-deoxy-4,5-O-isopropylidene-3-C-methyl-D-arabinitol 
• 115495-40-4 (2S,3S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-pentane-1,2,4-triol 
• 115495-43-7 (4R,5R)-5-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-hydroxy-2-phenylsulfanyl-hexanoic acid 
• 105676-50-4 (R)-5-[(R)-1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-3-phenylsulfanyl-dihydro-furan-2-one 
• 105676-51-5 2,3,5-trideoxy-5-C-methyl-6,7-O-isopropylidene-D-arabino-hept-2-eno-1,4-lactone 
• 105676-39-9 (3S,4R,5R)-5-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-methyl-hexane-1,2,4-triol 
• 105676-49-1 1,2-anhydro-3-deoxy-3-C-methyl-4,5-O-isopropylidene-D-arabinitol 

Downstream Products

• 936573-20-5 Acetic acid (1R,2S,3R,4R)-3-acetoxy-6-((3S,4R,5S,6S)-4,6-dimethyl-2,8-dioxa-bicyclo[3.2.1]oct-3-yl)-2,4-dimethyl-1-(2-trityloxy-ethyl)-hexyl ester 
• 936573-16-9 (3S,4S,5S,6S)-3-((Z)-(3R,4R,5S,6R)-4,6-Bis-benzyloxy-8-methoxymethoxy-3,5-dimethyl-oct-1-enyl)-4,6-dimethyl-2,8-dioxa-bicyclo[3.2.1]octane 
• 936495-46-4 ((2R,3R,4S,5R)-3,5-Bis-benzyloxy-6-[1,3]dithian-2-yl-2,4-dimethyl-hexyloxy)-tert-butyl-diphenyl-silane 
• 936495-48-6 ((2R,3R,4S,5R)-3,5-Bis-benzyloxy-7-methoxymethoxy-2,4-dimethyl-heptyloxy)-tert-butyl-diphenyl-silane 
• 936495-47-5 (3R,4S,5R,6R)-3,5-Bis-benzyloxy-7-(tert-butyl-diphenyl-silanyloxy)-4,6-dimethyl-heptan-1-ol 
• 936495-44-2 (2S,3S,4R,5R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexane-1,2-diol 
• 936495-45-3 ((2R,3R,4R)-3-Benzyloxy-2-methyl-4-(S)-oxiranyl-pentyloxy)-tert-butyl-diphenyl-silane 
• 936495-50-0 C₂₅H₃₅IO₄ 
• 936495-49-7 (2R,3R,4S,5R)-3,5-Bis-benzyloxy-7-methoxymethoxy-2,4-dimethyl-heptan-1-ol 
• 105676-42-4 [(2R,3R,4R)-3-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane 

Relevant academic research and scientific papers

Aplyronine A, a potent antitumor macrolide of marine origin, and the congeners aplyronines B and C: isolation, structures, and bioactivities

Aplyronine A (2), a potent antitumor macrolide was isolated from the sea hare Aplysia kurodai together with the congeners aplyronines B (3) and C (4). The absolute stereostructure of aplyronine A (2) was determined by the instrumental analysis (mainly NMR and MS) and the enantioselective synthesis of the fragments obtained from chemical degradation of aplyronine A (2). The structures of aplyronines B (3) and C (4) were also elucidated. Cytotoxicity and antitumor activity of aplyronine A (2) were evaluated.

Studies on the Stereochemistry of Aplyronine A: Determination of the Stereochemistry of the C21-C34 Fragment

The absolute stereochemistry of the C21-C34 fragment 2 of aplyronine A (1), a potent antitumor substance of marine origin, was determined by the enantioselective synthesis.