936495-45-3

Upstream product

• 936495-12-4 (E)-(R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-pent-2-enoic acid ethyl ester 
• 936495-15-7 (E)-(R)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-pent-2-en-1-ol 
• 77398-88-0 (S)-2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propionaldehyde 
• 936495-22-6 {(2S,3S)-3-[(S)-1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-oxiranyl}-methanol 
• 105676-42-4 [(2R,3R,4R)-3-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane 
• 105676-41-3 (2R,3R,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentan-3-ol 
• 105676-40-2 3,5-dideoxy-3,5-di-C-methyl-5,6-O-isopropylidene-D-talitol 
• 69743-60-8 (2S,3R)-threo-3-methylbutane-1,2,4-triol 1,2-acetonide 
• 936495-44-2 (2S,3S,4R,5R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexane-1,2-diol 

Downstream Products

• 936495-49-7 (2R,3R,4S,5R)-3,5-Bis-benzyloxy-7-methoxymethoxy-2,4-dimethyl-heptan-1-ol 
• 936495-50-0 C₂₅H₃₅IO₄ 
• 936495-47-5 (3R,4S,5R,6R)-3,5-Bis-benzyloxy-7-(tert-butyl-diphenyl-silanyloxy)-4,6-dimethyl-heptan-1-ol 
• 936495-48-6 ((2R,3R,4S,5R)-3,5-Bis-benzyloxy-7-methoxymethoxy-2,4-dimethyl-heptyloxy)-tert-butyl-diphenyl-silane 
• 936495-46-4 ((2R,3R,4S,5R)-3,5-Bis-benzyloxy-6-[1,3]dithian-2-yl-2,4-dimethyl-hexyloxy)-tert-butyl-diphenyl-silane 
• 936573-20-5 Acetic acid (1R,2S,3R,4R)-3-acetoxy-6-((3S,4R,5S,6S)-4,6-dimethyl-2,8-dioxa-bicyclo[3.2.1]oct-3-yl)-2,4-dimethyl-1-(2-trityloxy-ethyl)-hexyl ester 
• 936573-16-9 (3S,4S,5S,6S)-3-((Z)-(3R,4R,5S,6R)-4,6-Bis-benzyloxy-8-methoxymethoxy-3,5-dimethyl-oct-1-enyl)-4,6-dimethyl-2,8-dioxa-bicyclo[3.2.1]octane 

Relevant academic research and scientific papers

Aplyronine A, a potent antitumor macrolide of marine origin, and the congeners aplyronines B and C: isolation, structures, and bioactivities

Aplyronine A (2), a potent antitumor macrolide was isolated from the sea hare Aplysia kurodai together with the congeners aplyronines B (3) and C (4). The absolute stereostructure of aplyronine A (2) was determined by the instrumental analysis (mainly NMR and MS) and the enantioselective synthesis of the fragments obtained from chemical degradation of aplyronine A (2). The structures of aplyronines B (3) and C (4) were also elucidated. Cytotoxicity and antitumor activity of aplyronine A (2) were evaluated.

Studies on the Stereochemistry of Aplyronine A: Determination of the Stereochemistry of the C21-C34 Fragment

The absolute stereochemistry of the C21-C34 fragment 2 of aplyronine A (1), a potent antitumor substance of marine origin, was determined by the enantioselective synthesis.