105678-29-3

Usage

Chemical Structure

C14H23NO2

Molecular Weight

235.33

Appearance

Clear, colorless to pale yellow liquid

Solubility

Insoluble in water, soluble in most organic solvents

Uses

+ Pharmaceutical industry (intermediate in the synthesis of drugs and pharmaceuticals)
+ Anti-inflammatory and analgesic medications
+ Synthesis of various pesticides and agrochemicals
+ Organic chemistry (reagent in various synthetic reactions)

Safety Precautions

Potential toxicity and irritant properties (handle with caution)

Upstream product

• 75-24-1 trimethylaluminum 
• 126503-04-6 tert-butyl 2-methylpiperidine-1-carboxylate 
• 77-78-1 dimethyl sulfate 

Relevant academic research and scientific papers

Stereoselective nucleophilic addition reactions to cyclic n-acyliminium ions using the indirect cation pool method: Elucidation of stereoselectivity by spectroscopic conformational analysis and dft calculations

In this study, six-membered N-acyliminium ions were generated by the “indirect cation pool” method and reacted with several nucleophiles. These reactions afforded disubstituted piperidine derivatives with high diastereoselectivities and good to excellent

α-Lithioamine Synthetic Equivalents: Syntheses of Diastereoisomers from the Boc Piperidines

The α'-lithiations and electrophilic substitutions of selected Boc piperidines provide single or separable diastereoisomeric 2-substituted, 2,4-disubstituted, and 2,4,6-trisubstituted Boc piperidines which are readily hydrolyzed to the substituted piperidines.