105706-76-1

Usage

Uses

Used in Chemical Synthesis:
1-CBZ-PIPERIDINE-2-ALDEHYDE is used as a reactant in the kinetic resolution of racemic amino aldehydes. This process involves the selective oxidation of one enantiomer over the other, leading to the formation of chiral products with high enantiomeric purity. The use of copper(II)/(R,R)-Ph-BOX complex as a catalyst and N-iodosuccinimide as an oxidizing agent ensures a highly selective and efficient reaction.
Used in Pharmaceutical Industry:
1-CBZ-PIPERIDINE-2-ALDEHYDE serves as an important intermediate in the synthesis of various pharmaceutical compounds, particularly those with piperidine-based structures. Its unique reactivity and functional groups make it a valuable building block for the development of new drugs with potential applications in treating various medical conditions.
Used in Research and Development:
In the field of research and development, 1-CBZ-PIPERIDINE-2-ALDEHYDE is employed as a key compound for exploring new reaction pathways and understanding the reactivity of aldehydes with different catalysts and reagents. This knowledge can be applied to the design and synthesis of novel molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C14H17NO3/c16-10-13-8-4-5-9-15(13)14(17)18-11-12-6-2-1-3-7-12/h1-3,6-7,10,13H,4-5,8-9,11H2

Upstream product

• 28697-07-6 N-benzyloxycarbonyl D/L-pipecolinic acid 
• 501-53-1 benzyl chloroformate 
• 4043-87-2 pipecolic Acid 
• 105706-75-0 1-benzyloxycarbonyl-2-hydroxymethylpiperidine 

Downstream Products

• 105706-78-3 N-benzyloxycarbonyl-2-vinylpiperidine 
• 143321-98-6 ethyl-3-(N-benzyloxycarbonylpiperid-2-yl)-2-propenoate 
• 1229722-37-5 ethyl 3-(N-benzyloxycarbonylpyrrolin-2-yl)-2-propenoate 
• 1108739-05-4 (2S)-N-(benzyloxycarbonyl)piperidine-2-carboxaldehyde dimethylacetal 
• 60369-19-9 (2R)-N-(benzyloxycarbonyl)-2-(methoxycarbonyl)piperidine 
• 39945-51-2 benzyl 3-(hydroxymethyl)-1-piperidinecarboxylate 
• 1595280-78-6 (E)-benzyl 2-(4-(diallylamino)-4-oxobut-1-en-1-yl)piperidine-1-carboxylate 
• 1595280-77-5 (E)-benzyl 2-(4-(cyclohexylamino)-4-oxobut-1-en-1-yl)piperidine-1-carboxylate 
• 1595280-76-4 (E)-benzyl 2-(4-oxo-4-(phenylamino)but-1-en-1-yl)piperidine-1-carboxylate 
• 1595280-70-8 (E)-benzyl 2-(4-(benzylamino)-4-oxobut-1-en-1-yl)piperidine-1-carboxylate 
• 1595280-69-5 (E)-benzyl-2-(4-diazo-3-oxobut-1-en-1-yl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

Effecient kinetic resolution of racemic amino aldehydes by oxidation with N-iodosuccinimide

(Chemical Equation Presented) Selective recognition: The first efficient method for the kinetic resolution of racemic amino aldehydes (see scheme, PG=protecting group) is based on a copper(II)/(R,R)-Ph-BOX complex. The coordinated amino aldehydes were tra

Src kinase inhibitor compounds

Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.

Pyrrolidinic and piperidinic ring fission by conjugate elimination

Treating N-substituted pyrrolidines and piperidines bearing an allylic chain α to the nitrogen with strong bases leads to the opening of the heterocycle and provides 1,3-dienes disubstituted with an alkoxy and an aminoalkyl chain. The effects of the base and the solvent have been studied, as well as the influence of the ring size and the nitrogen substituent. The results obtained suggest a possible pre-chelation of the base cation before the deprotonation.

Methods for the stereoselective synthesis of substituted piperidines

One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will

The Synthesis of 1-Methyl-6,7,8,8a-tetrahydro-5H-indolizin-3-one by the Palladium-Catalyzed Cyclization of N-Bromoacetyl-2-vinylpiperidine

N-Bromoacetyl-2-vinylpiperidine underwent cyclizalion to give indolizidine derivative in the presence of a base and a catalytic amount of palladium trifluoroacetate.

New synthesis of heterocycles by use of palladium catalyzed cycli zation of α-haloamide with internal double bond

α-Haloamide having internal double bond was allowed to react with a catalytic amount of Pd(PPh3)4 in the presence of base to produce a cyclized product in a fairly good yield possibly through the intermediate of -alkylmetal complex. By use of this method, five and six membered lactams, pyrrolizidine and quinolizidine derivatives were synthesized in fairly good yields.