105746-13-2Relevant articles and documents
Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines
Pettersson, Fredrik,Svensson, Peder,Waters, Susanna,Waters, Nicholas,Sonesson, Clas
, p. 241 - 255 (2013/06/04)
A series of mono-substituted 4-phenylpiperidines and -piperazines have been synthesized and their effects on the dopaminergic system tested in vivo. The structure activity relationship (SAR) revealed that the position and physicochemical character of the
Determination of 1-aryl-4-propylpiperazine pKa values: The substituent on aryl modulates basicity
Lacivita, Enza,Leopoldo, Marcello,Giorgio, Paola De,Berardi, Francesco,Perrone, Roberto
experimental part, p. 1339 - 1344 (2009/08/08)
In order to design a potential drug, it is important to know its pKa because the protonation state of the molecule will be critical for ligand-receptor interaction and for the pharmacokinetic of the molecule. pKa values of a series o
Structure-activity relationship studies OF CNS agents. Part 10: 1-Aryl-2-[3-(4-aryl-1-piperazinyl)propyl]-1,4-dihydro-3(2H)-isoquinoli nones: Two modes of the interaction with the 5-HT(1A) receptor site
Mokrosz,Bojarski,Mackowiak,Bielecka,Boksa
, p. 328 - 333 (2007/10/02)
The synthesis and 5-HT(1A) and 5-HT2 receptor affinities of 1-aryl-2-[3-(4-aryl-1-piperazinyl)propyl]-1,4-dihydro-3(2H)-isoquinoli nones 7-28 are reported. The two derivatives 7 and 13 were the most potent 5-HT(1A) ligands (K(i) 1.72 ± 0.07 and
Liquid-crystalline Heterocycloalkanes. II. Syntheses and Liquid-crystalline Properties of Substituted 1-Phenylpiperazines
Suesse, M.,Skubatz, R.,Demus, D.,Zaschke, H.
, p. 349 - 358 (2007/10/02)
Several homologous series of the 1,4-disubstituted piperazines of the general formulas 4a-l, 6a-k, 7a, b, 8a-r were synthesized.Most of the new substances are liquid crystalline.Besides nematic phases also smectic phases of the types A, B and E exist, which was proved by texture and miscibility studies.
