1057507-66-0

Basic information

• Product Name: 6-amino-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-(3-sulfophenyl)-4,5-dihydro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine
• CAS NO: 1057507-66-0
• Molecular Weight: 495.949
• Mol File: 1057507-66-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-amino-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-(3-sulfophenyl)-4,5-dihydro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-(3-sulfophenyl)-4,5-dihydro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine(1057507-66-0)
• EPA Substance Registry System: 6-amino-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-(3-sulfophenyl)-4,5-dihydro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine(1057507-66-0)

Safety Data

• Hazardous Substances Data: 1057507-66-0(Hazardous Substances Data)

Upstream product

• 947-95-5 5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole 
• 50-01-1 guanidine hydrochloride 
• 119-17-5 1-(3'-sulfophenyl)-3-methyl-5-pyrazolone 

Relevant articles and documents

Facile one-pot synthesis and antimycobacterial evaluation of pyrazolo[3,4-d]pyrimidines

The present article describes a facile one-pot synthesis of a series of eight pyrazolo[3,4-d]pyrimidines 4a-h which were evaluated for their in-vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using the Alamar-Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. The compounds 4b, 4c, 4d, and 4g exhibited the best results (1.2 μg/mL) when compared with first-line drugs such as isoniazid (INH) and rifampicin (RIP). Therefore, this class of compounds could be a good starting point to develop new lead compounds in the treatment of multidrug-resistant tuberculosis.