1057670-91-3Relevant articles and documents
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
Bass, Jonathan Y.,Caldwell, Richard D.,Caravella, Justin A.,Chen, Lihong,Creech, Katrina L.,Deaton, David N.,Madauss, Kevin P.,Marr, Harry B.,McFadyen, Robert B.,Miller, Aaron B.,Parks, Derek J.,Todd, Dan,Williams, Shawn P.,Wisely, G. Bruce
scheme or table, p. 2969 - 2973 (2010/01/16)
Starting from the known FXR agonist GW 4064 1a, a series of alternately 3,5-substituted isoxazoles was prepared. Several of these analogs were potent full FXR agonists. A subset of this series, with a tether between the isoxazole ring and the 3-position aryl substituent, were equipotent FXR agonists to GW 4064 1a, with the 2,6-dimethyl phenol analog 1t having greater FRET FXR potency than GW 4064 1a.
Nitrogen-heterocyclic compound and process for production thereof
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Page column 16, (2010/01/30)
A nitrogen-heterocyclic compound is provided which is represented by General Formula (1): where R1and R2are independently hydrogen, an alkyl group, an aryl group, or a heteroaryl group; R3is hydrogen or an aryl group; Rsu
