105776-11-2Relevant articles and documents
Synthesis of 4,6-Dimethoxyindoles
Black, David St.C.,Kumar, Naresh,Wong, Laurence C. H.
, p. 15 - 20 (1986)
Syntheses are described for nine new 4,6-dimethoxyindoles, incorporating phenyl, pyridin-2-yl, methoxycarbonyl, carboxy and methyl groups in the 2- and/or 3-positions.
Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-α antagonists
Voss, Matthew E.,Carter, Percy H.,Tebben, Andrew J.,Scherle, Peggy A.,Brown, Gregory D.,Thompson, Lorin A.,Xu, Meizhong,Lo, Yvonne C.,Yang, Gengjie,Liu, Rui-Qin,Strzemienski, Paul,Everlof, J. Gerry,Trzaskos, James M.,Decicco, Carl P.
, p. 533 - 538 (2003)
Based on the realization that N-alkyl 5-arylidene-2-thioxo-1,3-thiazolidin-4-ones are tumor necrosis factor-α antagonists, we discovered two additional classes of antagonists: 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones (via rational design) and 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones (via computer-guided screening). Chemical modification of the lead structures showed that the structure-activity relationship profiles for both of these series were dependent on the electronic properties of the molecules. Subsequent studies showed that they were light-dependent inhibitors.
Indolecarboxylic compounds for inducing/stimulating hair growth and/or retarding hair loss
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, (2008/06/13)
Indolecarboxylic acid compounds and derivatives thereof, notably 4,6-dimethoxyindole-2-carboxylic acid and derivatives thereof, are especially useful for inducing/stimulating mammalian hair growth and/or preventing/retarding mammalian hair loss.
