105804-69-1

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• 1121-60-4 pyridine-2-carbaldehyde 
• 78539-98-7 (E)-pyridin-2-ylmethylene-hydrazine 
• 586-98-1 2-Hydroxymethylpyridine 

Relevant academic research and scientific papers

Synthesis and Characterization of Pyridine End-Capped Oligoazines

A new group of controlled chain length oligoazine analogues with pyridine end groups are synthesized and characterized.

The synthesis and structural characterisation of helical silver(I) complexes with short bis(pyridylimine) ligands

Three new disilver(I) double helicate complexes [Ag2L2][ClO4]2 (1), [Ag2L2][BF4]2 (2) [Ag2L2][NO3]2 (3) and a polymeric monohelical species [Ag2L′2][BF4]2 (4) have been generated via a self-assembly procedure to establish the effect of a side-chain on the subtle metal-ligand coding. The ligands, L = (C5H4N)C(CH3)=N-N=C(CH3)-(C 5H4N) and L′ = (C5H4N)CH=N-N=CH(C5H4N), were both readily prepared imine-based systems, in which the two bis-bidentate chelating units are separated by a single bond. Complexes 1, 2 and 3 adopt a double helical architecture, in which each silver centre is bound to two pyridylimine units in a distorted tetrahedral coordination geometry. Complex 4 is formed as an infinite monohelical polymer in which each silver centre is coordinated in a distorted tetrahedral geometry by two bidentate binding units from different ligands and the ligands are in turn coordinated to two silver(I) centres. While the two pyridylimine units of the ligand L are able to twist both in its free form and in the double helicates 1, 2 and 3, ligand L′ presents a planar conformation in both the free ligand and its monohelical complex 4. It is speculated that the arrangement of the two pyridylimine units around the N-N bond is essential to encode for a double helicate. Intra- and inter-molecular non-covalent interactions are found to stabilize the polymer 4 and provide opportunities for complexes 1, 2 and 3 to crystallize in different space groups.

Chromophore containing bipyridyl ligands. Part 1: Supramolecular solid-state structure of Ag(I) complexes

The solid-state structures of a series of azine or azo chromophore containing bipyridyl ligand complexes of Ag(i) salts have been determined by single-crystal X-ray diffraction. The supramolecular structures are dominated by one-dimensional chains formed through pyridyl-Ag-pyridyl bonding, but the packing of these chains through non-covalent intermolecular interactions is unpredictable. Ag...anion interactions are shown to be important, especially for nitrate and perchlorate species, but these may be supported or replaced by Ag...Ag, Ag...solvent, Ag...azine or Ag...π contacts. The molecular structures of the ligands show little alteration on complex formation, except for the AgNO3 complex of N,N′-bis-pyridin-4-ylmethylenehydrazine where the normally planar azine ligand adopts a twisted geometry. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2005.

RAMAN AND INFRARED SPECTROSCOPIC STUDIES OF NOVEL POLY-AZA CHAINS

The preliminary results concerning the synthesis, the structural and spectroscopic studies of a new series of linear poly-aza-molecules are reported in the present work.All the Raman spectra are characterized by a remarkable simplicity of the spectral features and exhibit a high degree of similitude with the spectra of polyene compounds.

Design, synthesis and biological evaluation of Schiff’s base derivatives as multifunctional agents for the treatment of Alzheimer’s disease

A series of Schiff’s base derivatives was rationally designed, synthesized, and evaluated as multi-function agents for the treatment of Alzheimer’s disease (AD). The results revealed that compound 3b was a novel multifunctional agent. It acted as a highly selective monoamine oxidase-B inhibitor (IC50 = 8.4 nM), which was explained by the docking study. Compound 3b also was an antioxidant agent (2.3 eq) and could significantly inhibit self-induced Aβ1-42 aggregation (31.8%). Meanwhile, compound 3b was a selective metal chelator and could inhibit Cu2+-induced Aβ1-42 aggregation (62.3%). Furthermore, compound 3b presented good neuroprotective effects on H2O2-induced PC12 cell injury. More importantly, compound demonstrated good blood brain barrier permeability and druglike properties. Therefore, compound 3b, a promising multi-targeted active molecule, offers an attractive starting point for further study in the drug-discovery process against AD.[Figure not available: see fulltext.].

Ligand Redox-Controlled Tandem Synthesis of Azines from Aromatic Alcohols and Hydrazine in Air: One-Pot Synthesis of Phthalazine

A controlled tandem synthetic route to azines from various alcohols and hydrazine hydrate by the use of a Ni(II) complex of 2,6-bis(phenylazo)pyridine as a catalyst is reported. In marked contrast to the previous report, the reaction is operative using an earth-abundant metal catalyst, milder reaction conditions, and aerobic conditions, which though are desirable but unprecedented in the literature. The catalytic reaction has a vast substrate scope including a single-step synthesis of phthalazine from 1,2-benzenedimethanol and hydrazine hydrate via intramolecular coupling. Mechanistic investigation suggests that the coordinated ligand redox controls the reaction by the use of a reversible azo (N=N)/ hydrazo (NH - NH) redox couple where the metal center is used primarily as a template.

Synthesis and evaluation of certain symmetrical schiff bases as inhibitors of MDA-MB-241 human breast cancer cell proliferation

A series of symmetrical Schiff base derivatives (L1-L7) were designed by a one-pot condensation reaction of various aldehyde/ketone compounds with hydrazine under mild conditions (room temperature, 3 days), using ether as solvent and acetic acid as catalyst. The target products were characterized and analysed by 1H and 13C NMR, FT-IR and liquid chromatography mass spectrometry (LC/MS). Our research focuses on the identification of synthetically chemotherapeutic substances able to inhibit, delay, or reverse the process of carcinogenesis in several stages. The target compounds presenting two regions for SAR evaluation were screened for their activity toward MDA-MB-241 breast cancer cell proliferation for the first time. Compound (1E, 2E)-1,2-bis(1-(3-nitrophenyl)ethylidene) hydrazine (L6) showed significant inhibitory activity (IC50 = 7.08 μg/mL).

The first controlled reduction of the high explosive RDX

The first reduction chemistry of the high explosive RDX that allows subsequent functionalization into a SERRS active species.