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6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine is a chemical compound with the molecular formula C6H6ClFN3. It is a derivative of pyrimidine and contains a chloro and fluoro substituent in its structure. 6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine has potential pharmaceutical applications and is used in the synthesis of various pharmaceutical intermediates. It may also have biological activity, making it of interest in medicinal chemistry research. Additionally, it is important to handle 6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine with care, as it may pose a hazard to health and the environment if not properly managed.

943006-45-9

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943006-45-9 Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure with chloro and fluoro substituents allows for the development of new compounds with potential therapeutic properties.
Used in Medicinal Chemistry Research:
6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine is used as a research compound in medicinal chemistry to explore its biological activity and potential applications in drug discovery. Its pyrimidine-based structure and substituents make it a promising candidate for further investigation and development.

Check Digit Verification of cas no

The CAS Registry Mumber 943006-45-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,3,0,0 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 943006-45:
(8*9)+(7*4)+(6*3)+(5*0)+(4*0)+(3*6)+(2*4)+(1*5)=149
149 % 10 = 9
So 943006-45-9 is a valid CAS Registry Number.

943006-45-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-chloro-5-fluoro-2-methylpyrimidin-4-amine

1.2 Other means of identification

Product number -
Other names 4-amino-6-chloro-5-fluoro-2-methylpyrimidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:943006-45-9 SDS

943006-45-9Relevant academic research and scientific papers

Structure-based design of a novel series of potent, selective inhibitors of the class i phosphatidylinositol 3-kinases

Smith, Adrian L.,D'Angelo, Noel D.,Bo, Yunxin Y.,Booker, Shon K.,Cee, Victor J.,Herberich, Brad,Hong, Fang-Tsao,Jackson, Claire L. M.,Lanman, Brian A.,Liu, Longbin,Nishimura, Nobuko,Pettus, Liping H.,Reed, Anthony B.,Tadesse, Seifu,Tamayo, Nuria A.,Wurz, Ryan P.,Yang, Kevin,Andrews, Kristin L.,Whittington, Douglas A.,McCarter, John D.,Miguel, Tisha San,Zalameda, Leeanne,Jiang, Jian,Subramanian, Raju,Mullady, Erin L.,Caenepeel, Sean,Freeman, Daniel J.,Wang, Ling,Zhang, Nancy,Wu, Tian,Hughes, Paul E.,Norman, Mark H.

experimental part, p. 5188 - 5219 (2012/08/28)

A highly selective series of inhibitors of the class I phosphatidylinositol 3-kinases (PI3Ks) has been designed and synthesized. Starting from the dual PI3K/mTOR inhibitor 5, a structure-based approach was used to improve potency and selectivity, resulting in the identification of 54 as a potent inhibitor of the class I PI3Ks with excellent selectivity over mTOR, related phosphatidylinositol kinases, and a broad panel of protein kinases. Compound 54 demonstrated a robust PD-PK relationship inhibiting the PI3K/Akt pathway in vivo in a mouse model, and it potently inhibited tumor growth in a U-87 MG xenograft model with an activated PI3K/Akt pathway.

CALCIUM CHANNEL ANTAGONISTS

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Page/Page column 32, (2010/11/27)

The present invention provides novel calcium channel antagonists, and methods of treating disease sates using the novel antagonists.

CALCIUM CHANNEL ANTAGONISTS

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Page/Page column 7-8, (2010/11/28)

The present invention provides novel calcium channel antagonists, and methods of treating disease sates using the novel antagonists.

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