1058161-66-2Relevant academic research and scientific papers
HETEROCYCLIC INHIBITORS OF GLUTAMINASE
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Page/Page column 113, (2013/06/06)
The invention relates to the heterocyclic compounds of Formula (I) as defined further herein, and pharmaceutical preparations thereof. The invention further relates to methods of treating cancer, immunological or neurological diseases using the heterocyclic compounds of the invention.
Synthesis and PKCθ inhibitory activity of a series of 4-indolylamino-5-phenyl-3-pyridinecarbonitriles
Dushin, Russell G.,Nittoli, Thomas,Ingalls, Charles,Boschelli, Diane H.,Cole, Derek C.,Wissner, Allan,Lee, Julie,Yang, Xiaoke,Morgan, Paul,Brennan, Agnes,Chaudhary, Divya
scheme or table, p. 2461 - 2463 (2009/12/25)
A series of 4-indolylamino-5-phenyl-3-pyridinecarbonitrile inhibitors of PKCθ were synthesized as potential anti-inflammatory agents. The effects of specific substitution on the 5-phenyl moiety and variations of the positional isomers of the 4-indolylamino substituent were explored. This study led to the discovery of compound 12d, which had an IC50 value of 18 nM for the inhibition of PKCθ.
PIPERAZINE AND PIPERIDINE MGLUR5 POTENTIATORS
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Page/Page column 40, (2008/12/07)
Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof, wherein A, B, D, Ar1, Ar2, R2, R3, R4, a, m and n are defined in the specification, methods for the use thereof, processes for making and pharmaceutical compositions containing the same.
