105849-96-5Relevant academic research and scientific papers
Superacid-promoted cyclodehydration leading to the imidazo[2,1-a] isoquinoline ring system
Kethe, Anila,Naredla, Rajasekhar Reddy,Klumpp, Douglas A.
, p. 1457 - 1461 (2013)
A series of heterocycle-substituted acetophenones were prepared and reacted with the Bronsted superacid CF3SO3H (triflic acid=trifluoromethanesulfonic acid). Cyclodehydration provided aryl-substituted imidazo[2,1-a]isoquinolines and related products (28-85%, seven examples). A mechanism is proposed involving dicationic intermediates. Copyright
