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3?(pyridin?3?yl)?1?p?tolyl?1H?pyrazol?5?amine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1058705-60-4

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1058705-60-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1058705-60-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,8,7,0 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1058705-60:
(9*1)+(8*0)+(7*5)+(6*8)+(5*7)+(4*0)+(3*5)+(2*6)+(1*0)=154
154 % 10 = 4
So 1058705-60-4 is a valid CAS Registry Number.

1058705-60-4Relevant academic research and scientific papers

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

McElroy, William T.,Tan, Zheng,Ho, Ginny,Paliwal, Sunil,Li, Guoqing,Seganish, W. Michael,Tulshian, Deen,Tata, James,Fischmann, Thierry O.,Sondey, Christopher,Bian, Hong,Bober, Loretta,Jackson, James,Garlisi, Charles G.,Devito, Kristine,Fossetta, James,Lundell, Daniel,Niu, Xiaoda

supporting information, p. 677 - 682 (2015/06/30)

IRAK4 is a critical upstream kinase in the IL-1R/TLR signaling pathway. Inhibition of IRAK4 is hypothesized to be beneficial in the treatment of autoimmune related disorders. A screening campaign identified a pyrazole class of IRAK4 inhibitors that were d

AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES

-

, (2012/10/08)

This invention relates to amidopyrazole compounds that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment of cellular proliferative diseases, for example, cancer, hyperplasia, restenosis, cardiac hypertrophy, immune disorders and inflammation.

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