1058710-35-2Relevant academic research and scientific papers
Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: Unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold
Sharma, Sameer,Rodriguez, Alice L.,Conn, P. Jeffrey,Lindsley, Craig W.
scheme or table, p. 4098 - 4101 (2009/05/26)
This Letter describes the synthesis and SAR, developed through an iterative analogue library approach, of a mGluR5 allosteric partial antagonist lead based on a 5-(phenylethynyl)pyrimidine scaffold. With slight structural modifications to the distal pheny
