1058744-83-4 Usage
Uses
Used in Pharmaceutical Industry:
3,21-Bis(acetyloxy)pregna-1,3,5,9(11),16-pentaen-20-one is used as a key intermediate in the synthesis of anti-inflammatory agents. It plays a crucial role in the development of corticosteroid drugs, which are widely used for treating various inflammatory conditions, such as allergies, asthma, and autoimmune disorders.
Additionally, due to its potent anti-inflammatory and immunosuppressive effects, 3,21-Bis(acetyloxy)pregna-1,3,5,9(11),16-pentaen-20-one can be utilized in the formulation of topical creams, ointments, and inhalers to provide targeted relief for skin conditions, respiratory issues, and other localized inflammations.
Check Digit Verification of cas no
The CAS Registry Mumber 1058744-83-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,8,7,4 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1058744-83:
(9*1)+(8*0)+(7*5)+(6*8)+(5*7)+(4*4)+(3*4)+(2*8)+(1*3)=174
174 % 10 = 4
So 1058744-83-4 is a valid CAS Registry Number.
1058744-83-4Relevant articles and documents
Improved synthesis of fluocinolone acetonide and process research of 6α,9α-fluorination
Tang, Jie,Zeng, Chunling,Xie, Longyong,Wang, Jinghua,Tian, Mi,Guo, Cancheng
, p. 110 - 112 (2018)
An efficient and improved synthetic route of fluocinolone acetonide with combination of bio-fermentation was developed from 21-acetyloxy-17α-hydroxy-4,9(11)-diene-3,20-dione (1a). Process of the 6α and 9α fluorination steps was studied, and it was observe
PROCESS FOR THE PREPARATION OF FLUOROTETRAENE
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Page/Page column 3, (2008/12/07)
There is provided a process for preparing 21-acetyloxy-6-alpha-fluoro-pregna-1,4,9(11),16-tetraene-3,20-dione compound of Formula I, which comprises reacting 21-acetyloxy-pregna-1,3,5,9(11),16-pentaene-3-oxo acetate with a fluorinating agent.
