2476-74-6

Usage

Uses

Used in Pharmaceutical Industry:
(6α)-21-(Acetyloxy)-6-fluoropregna-1,4,9(11),16-tetraene-3,20-dione is used as a key intermediate in the synthesis of anti-inflammatory agents. Its unique molecular structure allows it to modulate the immune system and reduce inflammation, making it a valuable component in the development of corticosteroid-based medications.
Used in Anti-inflammatory Applications:
(6α)-21-(Acetyloxy)-6-fluoropregna-1,4,9(11),16-tetraene-3,20-dione is employed as a precursor for the production of corticosteroids, which are widely used to treat various inflammatory conditions. Its role in the synthesis process is crucial, as it can be further modified to create potent anti-inflammatory drugs that can alleviate symptoms and improve the quality of life for patients suffering from conditions such as arthritis, asthma, and allergies.

Upstream product

• 1058744-83-4 3,21-diacetyloxy-pregna-1,3,5,9(11),16-pentaene-20-one 
• 37413-91-5 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate 

Relevant academic research and scientific papers

Method for preparing 6alpha-tetrafluoroyl acetate with high selectivity

The invention discloses a method for preparing 6alpha-tetrafluoroyl acetate with high selectivity. A reaction formula is as follows: (the formula is shown in the description.) The method comprises thefollowing steps: (1) mixing acetylide II and an acetylation reagent to obtain an esterification matter, concentrating, separating, and purifying, so as to obtain the esterification matter III-1, or directly applying to the preparation of next step without separating; (2) performing fluorination on the esterification matter III-1 by a selective fluorinating agent III-1, so as to generate a 6alpha-fluorine intermediate III; (3) performing metal catalyzing and oxidizing on the 6alpha-fluorine intermediate III, and converting into an aldehyde intermediate IV; (4) performing isomerization on the aldehyde intermediate IV, so as to generate a compound, namely 6alpha-tetrafluoroyl acetate I. The method has the advantages that the operation is simple and convenient, the reaction conditions are moderate, the selectivity is high, the product quality is good, and the method is suitable for industrial production.

Improved synthesis of fluocinolone acetonide and process research of 6α,9α-fluorination

An efficient and improved synthetic route of fluocinolone acetonide with combination of bio-fermentation was developed from 21-acetyloxy-17α-hydroxy-4,9(11)-diene-3,20-dione (1a). Process of the 6α and 9α fluorination steps was studied, and it was observe

PROCESS FOR THE PREPARATION OF FLUOROTETRAENE

There is provided a process for preparing 21-acetyloxy-6-alpha-fluoro-pregna-1,4,9(11),16-tetraene-3,20-dione compound of Formula I, which comprises reacting 21-acetyloxy-pregna-1,3,5,9(11),16-pentaene-3-oxo acetate with a fluorinating agent.