105896-43-3

Basic information

• Product Name: 1-Propene-2-sulfinamide, N-(4-methylphenyl)-
• CAS NO: 105896-43-3
• Molecular Formula: C10H13NOS
• Molecular Weight: 195.285
• Mol File: 105896-43-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Propene-2-sulfinamide, N-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propene-2-sulfinamide, N-(4-methylphenyl)-(105896-43-3)
• EPA Substance Registry System: 1-Propene-2-sulfinamide, N-(4-methylphenyl)-(105896-43-3)

Safety Data

• Hazardous Substances Data: 105896-43-3(Hazardous Substances Data)

Usage

Class of compound

sulfinamide

Contains

sulfur-nitrogen double bond

Usage

organic synthesis, production of pharmaceuticals and agrochemicals

Properties

versatile building block for preparation of complex molecules

Potential

biological activities, therapeutic agent

Importance

various applications in chemistry and pharmaceutical development

Upstream product

• 106-49-0 p-toluidine 
• 19977-37-8 methanesulfinic acid 4-methyl-anilide 
• 13291-18-4 isopropenylmagnesium bromide 
• 15795-42-3 N-sulfinyl-4-methylaniline 

Downstream Products

• 1196-79-8 2,5-Dimethyl-1H-indole 

Relevant articles and documents

Substituted N-aryl alk-1-enesulfinamides: Preparation, properties and conversion into the corresponding indole compounds [1]

Reaction of vinylic organometallic derivatives with N-sulfinyl arenamines 2 affords the title sulfinamides 3. On heating their solutions in selected solvents to 80-124 °C, these sulfinamides are converted into the corresponding indoles 6, probably via a [3.3]-sigmatropic rearrangement to intermediates VIII which undergo an intramolecular carbophilic reaction of the nitrogen atom with the neighboring sulfine group, followed by elimination of HSOH. The triethyloxonium tetrafluoroborate- or boron trifluoride etherate catalyzed conversion 3 → 6 can be carried out at a much lower temperature. Elsevier,.