105902-32-7

Upstream product

• 533-18-6 2-methylphenyl acetate 
• 66003-76-7 Diphenyliodonium triflate 
• 58109-40-3 diphenyliodonium hexafluorophosphate 
• 85630-35-9 N,N-diethyl-2-methylcarbamoyloxybenzene 
• 72569-05-2 ortho-methylphenyl pivalate 
• 7305-06-8 2-methyl-Ν,Ν-dimethylcarbamoyl phenolate 
• 36138-76-8 5-bromo-2-methylphenol 
• 98-80-6 phenylboronic acid 
• 864908-56-5 iso-propylcarbamic acid biphenyl-3-yl ester 
• 864908-50-9 O-4-methylbiphenyl-3-yl N-isopropylcarbamate 
• 7577-74-4 6-acetoxy-6-methylcyclohexa-2,4-dienone 
• 591-51-5 phenyllithium 
• 1100054-87-2 6-methylene-3-phenyl-2-cyclohexen-1-one 
• 580-51-8 [1,1'-biphenyl]-3-ol 

Downstream Products

• 35664-67-6 3-hydroxy-[1,1'-biphenyl]-4-carbaldehyde 
• 101093-75-8 6-acetoxy-6-methyl-3-phenyl-cyclohexa-2,4-dienone 

Relevant academic research and scientific papers

Copper-catalyzed meta-selective arylation of phenol derivatives: An easy access to m-aryl phenols

Achieving selective meta-functionalization of phenols is a significant challenge. Accessing such compounds generally needs elevated temperature or incorporation of complex templates. Here, we report a general approach to achieve meta-arylated phenols with a simple and common directing group. This coppercatalyzed protocol proceeds with complete meta-selectivity and tolerates a variety of functional groups in both coupling partners. Computational studies have revealed that the reaction proceeded via a Heck-like pathway.

Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents

New dialkylimidazole based sterol 14α-demethylase inhibitors were prepared and tested as potential anti-Trypanosoma cruzi agents. Previous studies had identified compound 2 as the most potent and selective inhibitor against parasite cultures. In addition, animal studies had demonstrated that compound 2 is highly efficacious in the acute model of the disease. However, compound 2 has a high molecular weight and high hydrophobicity, issues addressed here. Systematic modifications were carried out at four positions on the scaffold and several inhibitors were identified which are highly potent (EC50 1 nM) against T. cruzi in culture. The halogenated derivatives 36j, 36k, and 36p, display excellent activity against T. cruzi amastigotes, with reduced molecular weight and lipophilicity, and exhibit suitable physicochemical properties for an oral drug candidate.

Synthesis of substituted phenols by using the ring-closing metathesis/isoaromatization approach

Ring-closing olefin metathesis (RCM) of 4-methylene-1,7-octadien-3-ones 2, followed by isomerization of the carbon-carbon double bond of 6-methylene-2-cyclohexenones 3 from exo to endo, produced various phenols 4. As an application of the method, the RCM/

Substitution of hydroxybiaryls via directed ortho-lithiation of N-silylated O-aryl N-isopropylcarbamates

Herein we report regioselective substitution reactions of a series of 2- and 3-hydroxybiaryls including BINOL via a new directed ortho-metalation procedure. O-Aryl N-isopropylcarbamates, conveniently prepared from phenols and isopropyl isocyanate, are tem