1059180-48-1Relevant articles and documents
A short synthesis of [14C]-labelled levamisole and its major metabolite
Janssen, Cor G.M.,Thijssen, Jos B.A.,Verluyten, Willy L.M.
, p. 591 - 600 (2002)
Levamisole (I) is the levo isomer of tetramisole. It is a broad spectrum anthelmintic which is used extensively as a veterinary drug for food producing animals. Metabolism and environmental studies necessitated the synthesis of 14C-labelled levamisole (6) and of its major metabolite (12). 14C-Tetramisole was obtained in two steps from 14C-thiourea. Resolution via salt formation and crystallization afforded 14C-levamisole and 14C-dexamisole. Racemisation followed again by resolution made it possible to improve the over-all radiochemical yield of 14C-levamisole to 51.0%. The compound had a specific activity of 73.6 MBq/mmol, a HPLC purity of 99.8% and an enantiomeric excess of 99.4%. The 14C-labelled metabolite of levamisole (II) was obtained from 14C-potassium cyanate in 4 consecutive steps. Resolution via chiral HPLC afforded the desired compound in a 16.2% overall radiochemical yield. It had a specific activity of 895 MBq/mmol, a HPLC purity of 98.7% and an enantiomeric excess of 100%. Copyright
Preparation and addition of 3-bromo-2-oxotetrahydro-1,3-oxazoles to styrene and derivatives: Some new tetramisole intermediates
Dockx,De Knaep,Albert
, p. 511 - 513 (2007/10/02)
-
Process for preparing 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole
-
, (2008/06/13)
This disclosure relates to a process for the manufacture of compounds of the formula STR1 which comprises ring-closing a compound of the formula STR2 wherein the variables are as defined infra.
