1059191-27-3

Upstream product

• 6574-98-7 2,4-dichlorobenzylnitrile 
• 75-05-8 acetonitrile 

Downstream Products

• 1059191-28-4 4-amino-6-(2,4-dichlorophenyl)pyrimidine-2(1H)-thione 
• 1062197-39-0 ethyl [2-cyano-1-(2,4-dichlorophenyl)ethenyl]carbamate 

Relevant academic research and scientific papers

Alkylation of 2-(2,4-dichlorophenyl)-3-cyano-6-methyl-4-(1H-1,2,4-triazol-1-yl)methylpyridine at the methylene group

[Figure not available: see fulltext.] The reactivity of the 1-triazolyl- and 1-imidazolyl-substituted methylene groups at position 4 of pyridine ring toward alkyl halides is described. Nitrogen heterocycles attached to the methylene group, as well as a 3-cyano group effectively promoted the alkylation, offering a convenient method for constructing structurally diverse molecules that may present pharmaceutical interest.

SUBSTITUTED IMIDAZO- AND TRIAZOLOPYRIMIDINES, IMIDAZO- AND PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES

The invention relates to substituted imidazo- and triazolopyrimidines, imidazo- and pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological disorders, preferably of leukopenias and neutropenias.

SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES

The invention relates to substituted imidazopyrimidines and triazolopyrimidines, to methods for the production thereof, and to the use of same for producing medicaments for the treatment and/or prophylaxis of diseases, especially haematological diseases, preferably leucopenia and neutropenia.