1059196-13-2Relevant academic research and scientific papers
Pd(OAc)2-catalyzed cyclization of 2,3-allenoic acids in the presence of terminal αβ-unsaturated alkynones: A one-pot highly stereoselective synthesis of 4-(3′-oxo-1′(E)-alkenyl)-2(5H)- furanones
Chen, Guofei,Zeng, Rong,Gu, Zhenhua,Fu, Chunling,Ma, Shengming
, p. 4235 - 4238 (2008)
(Chemical Equation Presented) The Pd(OAc)2-catalyzed cyclization reaction of 2,3-allenoic acids in the presence of terminal αβ- unsaturated alkynones afforded an EIZ mixture of 4-(3′-oxo-1′- alkenyl)-2(5H)-furanones. A subsequent complete isomerization of the Z-isomer to E-isomer was observed in DMSO at 90 °C, which led to a highly stereoselective synthesis of 4-(3′-oxo-1′(E)-alkenyl)-2(5H)- furanones. A possible mechanism is proposed.
