105944-43-2Relevant articles and documents
Metal Complexes with Biologically Important Ligands, XLIV. - Platinum(II) and Palladium(II) as Amino Protecting Groups. Metal Complexes with Silyl Esters and Acid Chlorides as Ligands and Peptide Synthesis at the Complex
Steiner, Norbert,Ehrensdorfer, Eva,Chen, Jingtang,Beck, Wolfgang
, p. 275 - 280 (2007/10/02)
The cleavage of the chelate ring of platinum(II) and palladium(II) glycinate, cis-, trans-M(NH2CH2COO)2 (M = Pt, Pd), by trialkylchlorosilanes results in the formation of the complexes cis-, trans-MCl2(NH2CH2CO2SiR3)2 (1).Treatment of 1 or of cis-, trans-MCl2(NH2CHRCO2H)2, respectively, with oxalyl chloride and DMF gives the α-amino acid chloride complexes cis-, trans-MCl2(NH2CHRCOCl)2 (2) from which - using N-(trimethylsilyl)-α-amino acid esters - a series of dipeptide complexes cis-, trans-MCl2(dipeptideOR)2 (R = H, alkyl, SiMe3) (3) has been obtained. trans-Palladium complexes of type 3 and of type cis-PdCl2(HisNHCHRCO2Et) (4) are also formed from the corresponding α-amino acid complexes and α-amino acid esters with a water-soluble carbodiimide.