105945-24-2

Basic information

• Product Name: 3-(4-CHLORO-PHENOXY)-PHENYLAMINE
• Synonyms: 3-(4-CHLORO-PHENOXY)-PHENYLAMINE
• CAS NO: 105945-24-2
• Molecular Formula: C₁₂H₁₀ClNO
• Molecular Weight: 219.67
• Mol File: 105945-24-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 345.6 °C at 760 mmHg
• Flash Point: 162.8 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 6.11E-05mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: 3-(4-CHLORO-PHENOXY)-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLORO-PHENOXY)-PHENYLAMINE(105945-24-2)
• EPA Substance Registry System: 3-(4-CHLORO-PHENOXY)-PHENYLAMINE(105945-24-2)

Safety Data

• Hazardous Substances Data: 105945-24-2(Hazardous Substances Data)

Usage

General Description

3-(4-chloro-phenoxy)-phenylamine is a chemical compound that is composed of a 4-chloro-phenoxy group and a phenylamine group. 3-(4-CHLORO-PHENOXY)-PHENYLAMINE is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is known to exhibit certain biological activities, and has been studied for its potential use in the development of new medicines. Its chemical structure makes it useful for the modification and optimization of various bioactive compounds. 3-(4-CHLORO-PHENOXY)-PHENYLAMINE has the potential for further research and development in the fields of medicinal chemistry and drug discovery.

InChI:InChI=1/C12H10ClNO/c13-9-4-6-11(7-5-9)15-12-3-1-2-10(14)8-12/h1-8H,14H2

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 591-27-5 m-Hydroxyaniline 
• 37983-98-5 3-nitrophenyl 4-chlorophenyl ether 

Downstream Products

• 124457-33-6 1-[3-(4-chlorophenoxy)-phenyl]-4-(3-ethyl-1,2,4-oxadiazol-5-yl)-imidazole 
• 124457-74-5 1-[3-(4-chlorophenoxy)-phenyl]-4-(3-ethyl-1,2,4-oxadiazol-5-yl)-5-methoxymethylimidazole 
• 37940-85-5 3-(4-Chlorphenoxi)-trifluormethansulfonanilid 
• 17870-88-1 4-Chlor-N--anthranilsaeure 

Relevant articles and documents

Catalytic production of anilines by nitro-compounds hydrogenation over highly recyclable platinum nanoparticles supported on halloysite nanotubes

Pt-nanoparticles supported on halloysite-nanotubes (HNTs) were selectively deposited onto the inner (Pt(IN)/HNT) or outer (Pt(OUT)/HNT) surface of the support to evaluate their operational stability on the cleaner and efficient hydrogenation of nitro compounds to produce their corresponding anilines. The formation of Pt0-aggregates on the inner or outer surfaces was observed, with mean particles sizes of 2.4–2.9 nm. The catalysts were evaluated using ethanol as solvent and nitrobenzene as a model substrate at a temperature of 298 K, under 1 bar of H2 pressure. The Pt(IN)/HNT catalyst showed better catalytic performance than Pt(OUT)/HNT, which was mainly attributed to the confinement effect of the Pt-nanoparticles inside the HNTs. However, the operational stability showed that Pt(OUT)/HNT retained its catalytic performance after 15 cycles, while the Pt(IN)/HNT catalyst suffered deactivation after the 5th cycle. The best catalytic system showed a moderate-to-high efficiency in the efficient hydrogenation of 7 nitro compounds used to produce their corresponding anilines, which are important pharmaceutical building blocks.

1H,3H-PYRROL[1,2-c]THIAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

A compound of the general formula I; STR1 in which R is hydrogen or a halogen or an alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, carboxy, alkylsulphinyl, alkylsulphonyl, sulphamido, alkylsulphamido, dialkylsulphamido, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, phenylcarbamoyl, diphenylcarbamoyl, pyridylcarbamoyl, dipyridylcarbamoyl, benzyl, alkylcarbonyl, benzoyl, alkyloxycarbonyl, phenoxycarbonyl, alkylcarbonyloxy, benzoyloxy, alkylcarbonylamino, benzamido, phenyl, phenoxy or phenylthio group, X is oxygen or sulphur or an imino, alkylimino, phenylimino, benzylimino, sulphinyl, sulphonyl, carbonyl, carbonylmethylene, methylenecarbonyl, carbonylvinylene or vinylenecarbonyl group, or X represents a valency bond or a straight-chain alkylene group containing 1 to 4 carbon atoms and Ar is a phenyl, naphthyl, pyridyl, quinolinyl, isoquinolinyl, thienyl, benzothienyl, thieno 3,2-b!thien-2-yl or thieno 2,3-b!thien-2-yl group, it being possible for the group Ar to be unsubstituted or substituted with one or more halogen or alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, carboxy, alkylsulphinyl, alkylsulphonyl, sulphamido, alkylsulphamido, dialkylsulphamido, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, phenylcarbamoyl, diphenylcarbamoyl, pyridylcarbamoyl, dipyridylcarbamoyl, benzyl, alkylcarbonyl, benzoyl, alkyloxycarbonyl, phenoxycarbonyl, alkylcarbonyloxy, benzoyloxy, alkylcarbonylamino or benzamido group;each alkyl moiety containing 1 to 4 straight-or branched-chain carbon atoms; the compound being in separate enantiomeric form or mixtures thereof or a pharmaceutically acceptable salt thereof is useful in the treatment of all the pathological conditions in which PAF-acether may be directly or indirectly implicated.