105955-04-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Heptanone, 5-hydroxy-1-(4-hydroxyphenyl)-7-phenylis used as a pharmaceutical agent for its antioxidant properties. Its ability to neutralize free radicals and protect cells from oxidative damage makes it a promising candidate for the development of drugs targeting various diseases and conditions related to oxidative stress.
Used in Cosmetics Industry:
In the cosmetics industry, 3-Heptanone, 5-hydroxy-1-(4-hydroxyphenyl)-7-phenylis used as an active ingredient in skincare products. Its antioxidant properties help to protect the skin from environmental stressors and promote a healthy, youthful appearance.
Used in Food Production:
3-Heptanone, 5-hydroxy-1-(4-hydroxyphenyl)-7-phenylis used in the food production industry as a natural preservative. Its antioxidant properties help to extend the shelf life of food products by preventing the oxidation of fats and oils, thus maintaining the quality and freshness of the products.

Upstream product

• 7074-09-1 4-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]butan-2-one 
• 5471-51-2 4-(4-hydroxyphenyl)-2-oxobutane 
• 1158558-75-8 3-(4-hydroxy-phenethyl)-5-phenethyl-4,5-dihydro-isoxazole 
• 1062083-17-3 1-(4-hydroxyphenyl)-7-phenyl-(6E)-6-hepten-5-ol-3-one 
• 256946-31-3 5-hydroxy-7-phenyl-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-heptan-3-one 

Downstream Products

• 1062083-22-0 1-(4 hydroxyphenyl)-7-phenyl-hept-4-en-3-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor α and β agonists

In this work, 52 diphenyl-4,5-dihydroisoxazoles and -3-hydroxy ketones were prepared and their estrogen receptor α (ERα) and estrogen receptor β (ERβ) activities were explored in order to systematize and maximize their biological activity. The biological

Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: Isolation, chemical modification and estrogenic activity evaluation

Three new diarylheptanoids, a 1:2 mixture of (3S)- and (3R)-1-(4-methoxyphenyl)-7-phenyl-(6E)-6-hepten-3-ol (13a and 13b) and 1-(4-hydroxyphenyl)-7-phenyl-(6E)-6-hepten-3-one (15), together with two synthetically known diarylheptanoids 1,7-diphenyl-(1E,3E,5E)-1,3,5-triene (9) and 1-(4-hydroxyphenyl)-7-phenyl-(4E,6E)-4,6-heptadien-3-one (16), and nine known diarylheptanoids, 2, 8, 10-12, 14, a 3:1 mixture of 17a and 17b, and 18, were isolated from the rhizomes of Curcuma comosa Roxb. The absolute stereochemistry of the isolated compounds has also been determined using the modified Mosher's method. The isolated compounds and the chemically modified analogues were evaluated for their estrogenic-like transcriptional activity using RT-PCR in HeLa cell line. Some of the isolated diarylheptanoids and their modified analogues exhibited estrogenic activity comparable to or higher than that of the phytoestrogen genistein. Based on the transcriptional activation of both estrogenic targets, Bcl-xL and ERβ gene expression, the structural features for a diarylheptanoid to exhibit high estrogenic activity are the presence of an olefinic function conjugated with the aromatic ring at the 7-position, a keto group at the 3-position, and a phenolic hydroxyl group at the p-position of the aromatic ring attached to the 1-position of the heptyl chain.

Synthesis and digestibility inhibition of diarylheptanoids: Structure- activity relationship

(±)-5-Hydroxy-1,7-bis-(4'-hydroxyphenyl)-3-heptanone (2a), (±)5- hydroxyl-1-(4'-hydroxyphenyl)-7-phenyl-3-heptanone (2b), (±)-5-hydroxy-7- (4'-hydroxyphenyl)-1-phenyl-3-heptanone (2c), and (±)-5-hydroxy-1,7- bis(phenyl)-3-heptanone (2d) have been synthesized to study the structure- activity relationship regarding digestibility inhibition in vitro in cow rumen fluid. The activities were compared with the activity of chiral (S)-2a and its glucoside platyphylloside (1), isolated from Betula pendula. Compound 2a was slightly less active, 2b and 2c were more active, and 2d was less active than (S)-2a and platyphylloside.