1059596-63-2

Upstream product

• 106-45-6 para-thiocresol 
• 7432-21-5 N-carbobenzyloxy-L-tryptophane 

Downstream Products

• 1059597-28-2 (S)-benzyl 3-(1H-indol-3-yl)-1-(1-methyl-1H-indol-2-yl)-1-oxopropan-2-ylcarbamate 
• 1446350-40-8 N-Cbz-L-Trp-L-Phe-OEt 
• 17689-58-6 N-(benzyloxycarbonyl)-L-tryptophanyl-L-tryptophan methyl ester 
• 1399858-73-1 N-Cbz-L-Trp-L-His-OMe 
• 136095-64-2 N-Cbz-L-Trp-L-Ser-OEt 
• 2419-36-5 Cbz-Trp-Leu-OMe 
• 2891-15-8 (S)-ethyl 2-(2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)acetate 

Relevant academic research and scientific papers

HMDO-promoted peptide and protein synthesis in ionic liquids

Hexamethyldisiloxane (HMDO) has been developed to efficiently promote the metal-free direct coupling of an amino function of one cysteine-free peptide or protein and a C-terminal thioester of the second peptide in ionic liquids. The amide-coupling reaction proceeds smoothly under mild conditions to afford the corresponding products in good to excellent yields (63-94%). Peptide couplings were also achieved using in-situ-generated thioesters by the thioesterification of oxo esters.

Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters

Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters in the presence of bis(trimethylsilyl) acetamide (BSA) has been developed. This general method provides convenient access to N-protected peptides in good yields under mild condi

Synthesis of high enantiopurity N-protected α-amino ketones by thiol ester-organostannane cross-coupling using pH-neutral conditions

(Chemical Equation Presented) An efficient synthesis of high enantiopurity N-protected α-amino ketones is described. Complementing other studies using boronic acids and thiol esters, this Cu(I) diphenylphosphinate (CuDPP)-mediated, palladium-catalyzed cou