2419-36-5

Usage

Uses

Used in Pharmaceutical Research:
L-Leucine, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-, methyl ester is used as a research compound for investigating the mechanisms of cellular function. Its unique structure and properties allow scientists to explore its potential therapeutic applications in the development of new pharmaceutical compounds.
Used in Protein Synthesis Studies:
In the field of molecular biology, L-Leucine, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-, methyl ester is used as a model compound to study the process of protein synthesis. Its interaction with cellular machinery can provide insights into the regulation of protein production and the factors that influence it.
Used in Muscle Growth Research:
L-Leucine, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-, methyl ester is used as a research tool in the study of muscle growth. Its effects on muscle tissue and the underlying biological processes can help researchers understand the factors that contribute to muscle development and potentially lead to the development of therapeutic interventions for muscle-related conditions.
Used in Neurotransmitter Regulation Research:
In the field of neuroscience, L-Leucine, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-, methyl ester is used as a research compound to study the regulation of neurotransmitters. Its influence on neurotransmitter systems can provide valuable information on the role of these chemicals in brain function and the potential for developing treatments for neurological disorders.

Upstream product

• 1059596-63-2 N-Cbz-L-tryptophan p-tolylthiol ester 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 7432-21-5 N-carbobenzyloxy-L-tryptophane 
• 2666-93-5 (S)-Leu-OMe 

Downstream Products

• 403655-45-8 (3S,6S)-(-)-6-(1-benzoyloxyindol-3-ylmethyl)-3-isobutyl-2,5-piperazinedione 
• 56941-94-7 Cyclo(L-leucyl-L-tryptophyl) 

Relevant academic research and scientific papers

Synthetic minimalistic tryptophan zippers as a chiroptical switch

In this paper, we presented a new design strategy for a peptide-based chiral supramolecular assembly. A series of aryl linked peptides 1a-1f were designed and synthesized. The bis-urea peptides 1a-1c self-assembled into a helical supramolecular arrangement resembling Trp zipper (Trpzip) structures present in proteins. Interestingly, a dihydrogenphosphate anion, upon binding to the assembly, could invert the chirality of the supramolecular assembly which could be reverted to the original by the addition of water. This chiroptical behavior can be repeated several times. Microscopy analysis showed that the supramolecular helices were assembled to form spheres. In addition to that, we also found that the handedness of supramolecular chirality is dependent on the position of Trp residues on the aromatic scaffold. Both left and right handed helical supramolecular arrangements were obtained by placing l-Trp residues at different positions on the aromatic core. The unprecedented Trpzip in these designed small peptidomimetics will stimulate more work in the area of peptide-based assemblies.

Urea-cored peptides for anion binding and vesicle formation

Urea and urea-triazole cored peptides were synthesized and characterized. These compounds were analyzed for their potency to sense anions such as F-, Cl-, Br-, I-, H2PO4 - and HSO4 - by UV-

HMDO-promoted peptide and protein synthesis in ionic liquids

Hexamethyldisiloxane (HMDO) has been developed to efficiently promote the metal-free direct coupling of an amino function of one cysteine-free peptide or protein and a C-terminal thioester of the second peptide in ionic liquids. The amide-coupling reaction proceeds smoothly under mild conditions to afford the corresponding products in good to excellent yields (63-94%). Peptide couplings were also achieved using in-situ-generated thioesters by the thioesterification of oxo esters.

Three types of induced tryptophan optical activity compared in model dipeptides: Theory and experiment

The tryptophan (Trp) aromatic residue in chiral matrices often exhibits a large optical activity and thus provides valuable structural information. However, it can also obscure spectral contributions from other peptide parts. To better understand the indu

Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters

Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters in the presence of bis(trimethylsilyl) acetamide (BSA) has been developed. This general method provides convenient access to N-protected peptides in good yields under mild condi

Simple synthesis of 1,3,4,5a,6,10b,11,11a-octahydro-2H-pyrazino[1′,2′:1,5]pyrrolo[2, 3-b]indole derivatives based on 1-hydroxyindole chemistry

3-Substituted (3S,6S)-6-(1-hydroxyindol-3-ylmethyl)-2,5-piperazinediones are prepared for the first time. They are shown to be suitable intermediates for the synthesis of 3,10b-disubstituted (3S,5aR,10bS,11as)-1,3,4,5a,6,10b,11, 11a-octahydro-2H-pyrazino[