1059631-10-5Relevant academic research and scientific papers
New highlights in the synthesis and reactivity of 1,4-dihydropyrazine derivatives
Chaignaud, Mathilde,Gillaizeau, Isabelle,Ouhamou, Nouara,Coudert, Gérard
, p. 8059 - 8066 (2008)
In the course of our investigations on the synthesis of original nitrogen heterocyclic derivatives, we were interested in the synthesis and study of original 1,4-dihydropyrazine rings. To this aim the desired bisvinylphosphate derivative was prepared from N-Boc piperazine-2,5-dione and then was engaged in palladium catalyzed reactions (reduction, Suzuki and Stille cross-coupling reactions). The 1,4-dihydropyrazine and the corresponding 2,5-disubstituted derivatives were obtained in fair to good yields and were then functionalized under anionic conditions. Aromatization into 1,4-pyrazines was investigated in a second stage.
P-C cross-coupling onto enamides: Versatile synthesis of α-enamido phosphane derivatives
Cieslikiewicz, Monika,Bouet, Alexis,Juge, Sylvain,Toffano, Martial,Bayardon, Jerome,West, Caroline,Lewinski, Krzystof,Gillaizeau, Isabelle
scheme or table, p. 1101 - 1106 (2012/04/10)
We report herein the Pd-catalyzed P-C cross-coupling reaction between enol phosphates and secondary phosphane-borane complexes or phosphane oxides. The reaction was performed under mild conditions, owing to Pd activation of the P-H bonds of the phosphane-
