N,N-bis(tert-butoxycarbonyl)-2,5-bis(diphenyloxy-phosphoryloxy)-[1,4]-dihydropyrazine

Base Information

• Chemical Name: N,N-bis(tert-butoxycarbonyl)-2,5-bis(diphenyloxy-phosphoryloxy)-[1,4]-dihydropyrazine
• CAS No.: 1059631-10-5
• Molecular Formula: C₃₈H₄₀N₂O₁₂P₂
• Molecular Weight: 778.689
• Mol file: 1059631-10-5.mol

Synonyms:N,N-bis(tert-butoxycarbonyl)-2,5-bis(diphenyloxy-phosphoryloxy)-[1,4]-dihydropyrazine

Chemical Property of N,N-bis(tert-butoxycarbonyl)-2,5-bis(diphenyloxy-phosphoryloxy)-[1,4]-dihydropyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N,N-bis(tert-butoxycarbonyl)-2,5-bis(diphenyloxy-phosphoryloxy)-[1,4]-dihydropyrazine

There total 1 articles about N,N-bis(tert-butoxycarbonyl)-2,5-bis(diphenyloxy-phosphoryloxy)-[1,4]-dihydropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

di-tert butyl-2,5-dioxopiperzine-1,4-dicarboxylate (151692-07-8) + chlorophosphoric acid diphenyl ester (2524-64-3) → N,N-bis(tert-butoxycarbonyl)-2,5-bis(diphenyloxy-phosphoryloxy)-[1,4]-dihydropyrazine (1059631-10-5)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

DOI:10.1016/j.tet.2008.06.080

Reference yield: 75.0%

N,N-bis(tert-butoxycarbonyl)-2,5-bis(diphenyloxy-phosphoryloxy)-[1,4]-dihydropyrazine (1059631-10-5) + (S,S)-(-)-1-r-oxo-2-c,5-t-diphenylphospholane (474093-57-7) → di-tert-butyl bis((2S,5S)-1-oxo-2,5-diphenyl-λ5-phospholan-1-yl)pyrazine-1,4-dicarboxylate (1372716-19-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃; for 2h; optical yield given as %ee; stereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201101293

Reference yield: 72.0%

N,N-bis(tert-butoxycarbonyl)-2,5-bis(diphenyloxy-phosphoryloxy)-[1,4]-dihydropyrazine (1059631-10-5) + phenylboronic acid (98-80-6) → N,N-bis(tert-butoxycarbonyl)-2,5-diphenyl-[1,4]-dihydropyrazine (1059631-24-1)

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; for 2h; Heating;

DOI:10.1016/j.tet.2008.06.080

upstream raw materials:

di-tert butyl-2,5-dioxopiperzine-1,4-dicarboxylate

chlorophosphoric acid diphenyl ester

Downstream raw materials:

N,N-bis(tert-butoxycarbonyl)-2,5-bis(2-phenylethynyl)-[1,4]-dihydropyrazine

N,N-bis(tert-butoxycarbonyl)-2,5-diphenyl-[1,4]-dihydropyrazine

di-tert-butyl bis((2S,5S)-1-oxo-2,5-diphenyl-λ5-phospholan-1-yl)pyrazine-1,4-dicarboxylate