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Usage

Uses

Used in Food Industry:
Ethyl 4-(4-bromophenyl)butanoate is used as a flavoring agent for its sweet, fruity odor, enhancing the taste of various food products.
Used in Fragrance Industry:
Ethyl 4-(4-bromophenyl)butanoate is used as a fragrance ingredient, contributing to the creation of various scents in perfumes and other scented products.
Used in Pharmaceutical Industry:
Ethyl 4-(4-bromophenyl)butanoate is used as an intermediate in the synthesis of various pharmaceuticals, playing a crucial role in the development of new drugs.
Used in Agrochemical Industry:
Ethyl 4-(4-bromophenyl)butanoate is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Insecticidal Applications:
Ethyl 4-(4-bromophenyl)butanoate is used as an insecticide, leveraging its insecticidal properties to control pests in agricultural settings.
Used in Antimicrobial Applications:
Ethyl 4-(4-bromophenyl)butanoate is used for its antimicrobial properties, helping to prevent the growth of bacteria and other microorganisms in various applications. However, it is important to handle ethyl 4-(4-broMophenyl)butanoate with care, as it may cause skin and eye irritation upon contact.

InChI:InChI=1/C12H15BrO2/c1-2-15-12(14)5-3-4-10-6-8-11(13)9-7-10/h6-9H,2-5H2,1H3

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 623-51-8 ethyl 2-sulfanylacetate 
• 19493-09-5 Methylenetriphenylphosphorane 
• 623-73-4 diazoacetic acid ethyl ester 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 108-86-1 bromobenzene 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 6340-79-0 4-oxo-4-(4-bromophenyl)butanoic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 104089-17-0 ethyl 4-(iodozincio)butanoate 
• 64-17-5 ethanol 
• 35656-89-4 4-(4-bromophenyl)butanoic acid 
• 27200-79-9 p-bromophenylacetaldehyde 

Downstream Products

• 98453-60-2 6-bromo-3,4-dihydro-4,4-dimethylnaphthalen-1(2H)-one 
• 128994-29-6 (S)-(-)-γ-(p-Bromophenyl)-γ-butyrolactone 
• 126135-43-1 (R)-(+)-γ-(p-Bromophenyl)-γ-butyrolactone 
• 30913-87-2 4-(4-bromophenyl)-4-oxobutanoic acid ethyl ester 
• 117713-14-1 4-(but-3-en-1-yl)-4'-methyl-1,1'-biphenyl 
• 74003-07-9 ethyl 4-<4-(1-imidazolyl)phenyl>butyrate 

Relevant academic research and scientific papers

Visible-light induced metal-free cascade Wittig/hydroalkylation reactions

Cascade reactions are green and powerful transformations for building multiple carbon-carbon bonds in one step. Through a relay olefination and radical addition process, we were able to develop the cascade Wittig/hydroalkylation reactions induced by visible light. This metal-free radical approach features mild conditions, robustness, and excellent functionality compatibility. It allows access to saturated C3 homologation products directly from aldehydes or ketones. The synthetic utility of this method is demonstrated by a two-step synthesis ofindolizidine 209D.

Radical-Mediated Strategies for the Functionalization of Alkenes with Diazo Compounds

One of the most common reactions of diazo compounds with alkenes is cyclopropanation, which occurs through metal carbene or free carbene intermediates. Alternative functionalization of alkenes with diazo compounds is limited, and a methodology for the addition of the elements of Z-CHR2 (with Z = H or heteroatom, and CHR2 originates from N2 CR2) across a carbon-carbon double bond has not been reported. Here we report a novel reaction of diazo compounds utilizing a radical-mediated addition strategy to achieve difunctionalization of diverse alkenes. Diazo compounds are transformed to carbon radicals with a photocatalyst or an iron catalyst through PCET processes. The carbon radical selectively adds to diverse alkenes, delivering new carbon radical species, and then forms products through hydroalkylation by thiol-assisted hydrogen atom transfer (HAT), or forms azidoalkylation products through an iron catalytic cycle. These two processes are highly complementary, proceed under mild reaction conditions, and show high functional group tolerance. Furthermore, both transformations are successfully performed on a gram-scale, and diverse γ-amino esters, γ-amino alcohols, and complex spirolactams are easily prepared with commercially available reagents. Mechanistic studies reveal the plausible pathways that link the two processes and explain the unique advantages of each.

Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations

Chemical transformations that install heteroatoms into C?H bonds are of significant interest because they streamline the construction of value-added small molecules. Direct C?H oxyfunctionalization, or the one step conversion of a C?H bond to a C?O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymatic process for direct C?H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.

HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS

The invention relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): (I), wherein L1, A, X1, X2, R1, R2, and R3 are described herein.

Detailed mechanistic studies on palladium-catalyzed selective C-H olefination with aliphatic alkenes: A significant influence of proton shuttling

Directing group-assisted regioselective C-H olefination with electronically biased olefins is well studied. However, the incorporation of unactivated olefins has remained largely unsuccessful. A proper mechanistic understanding of olefination involving un

ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS

Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity

Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.

Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity

Compounds of the formula STR1 have retinoid-like or retinoid antagonist-like biological activity.

Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity

Compounds of the formula STR1 having retinoid like biological activity.

ARYLATION AND VINYLATION OF 2-CARBOETHOXYETHYLZINC IODIDE AND 3-CARBOETHOXYPROPYLZINC IODIDE CATALYZED BY PALLADIUM

By the palladium catalysis 2-carboethoxyethylzinc iodide reacts with aryl iodides and vinyl iodides or triflates to provide the coupling products (ethyl 3-arylpropionates and ethyl 4-pentenoates, respectively) in satisfactory yields.The similar coupling reaction is observed for the reaction with 3-carboethoxypropylzinc iodide.