105995-07-1Relevant academic research and scientific papers
Diverse copper(iii) trifluoromethyl complexes with mono-, bi- and tridentate ligands and their versatile reactivity
Zhang, Song-Lin,Xiao, Chang,Wan, Hai-Xing
, p. 4779 - 4784 (2018)
Cu(iii) trifluoromethyl complexes are proposed as essential intermediates for many copper-promoted trifluoromethylation reactions, but remain elusive and scarcely explored. We report herein the isolation and spectroscopic and X-ray crystallographic charac
Syn-Fluoro- and -Oxy-trifluoromethylation of Arylacetylenes
Zhang, Song-Lin,Wan, Hai-Xing,Bie, Wen-Feng
supporting information, p. 6372 - 6375 (2017/12/08)
One-step concurrent fluoro-trifluoromethylation across the triple bond of arylacetylenes in a syn mode is enabled by the collaboration of (phen)CuIII(CF3)3 and CsF that produces chemo-, regio-, and stereoselectively (Z)-α-fluoro-β-CF3 styrenes. This method can be extended to achieve syn-oxy-trifluoromethylation and syn-aryl-trifluoromethylation of alkynes using phenoxides, alkoxides, or phenylboronic acid in place of CsF. It opens up new opportunities for preparing various functionalized trifluoromethylated Z-alkenes and demonstrates the potential of Cu(III)-CF3 complexes in organic synthesis.
ON THE ROLE OF THE CF3 GROUP IN DETERMINING THE RELATIVE STABILITY OF E, Z-ISOMERS
Bumgardner, Carl L.,Bunch, John E.,Whangbo, M.-H.
, p. 1883 - 1886 (2007/10/02)
Although base-catalyzed addition of PhSH to PhCCCF3 under thermodynamic control gives E-Ph(PhS)C=CH(CF3), Z-Ph(PhO)C=CH(CF3) is the thermodynamically favored product from similar reaction of PhOH with PhCCCF3.The preference for the cis-configuration
