105995-73-1

Basic information

• Product Name: 5-BROMO-2-ETHYNYL-THIOPHENE
• Synonyms: 5-BROMO-2-ETHYNYL-THIOPHENE;2-BroMo-5-ethynylthiophene
• CAS NO: 105995-73-1
• Molecular Formula: C₆H₃BrS
• Molecular Weight: 187.05702
• Mol File: 105995-73-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 5-BROMO-2-ETHYNYL-THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-ETHYNYL-THIOPHENE(105995-73-1)
• EPA Substance Registry System: 5-BROMO-2-ETHYNYL-THIOPHENE(105995-73-1)

Safety Data

• Hazardous Substances Data: 105995-73-1(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-ethynyl-thiophene is a chemical compound that belongs to the class of thiophenes, which are aromatic five-membered heterocycles containing a sulfur atom. 5-BROMO-2-ETHYNYL-THIOPHENE is characterized by the presence of a bromine atom at the 5-position and an ethynyl group at the 2-position of the thiophene ring. It is commonly used in various organic synthesis reactions, particularly in the formation of complex organic molecules. Its structure and reactivity make it a valuable building block for the synthesis of pharmaceuticals, agrochemicals, and materials with advanced properties. Additionally, 5-Bromo-2-ethynyl-thiophene has potential applications in the field of organic electronics, as it can be incorporated into organic semiconductors for use in electronic devices such as organic light-emitting diodes (OLEDs) and organic photovoltaic cells.

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 606925-57-9 ((5-bromothiophene-2-yl)ethynyl)trimethylsilane 

Relevant articles and documents

Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats

In this paper we describe the design and synthesis of bis(Het)Aryl-1,2,3-triazole quinuclidine α7R ligands using an efficient three-step sequence including a Suzuki-Miyaura cross coupling reaction with commercially available and home-made boron derivatives. The exploration of SAR required the preparation of uncommon boron derivatives. Forty final drugs were tested for their ability to bind the target and nine of them exhibited Ki values below nanomolar concentrations. The best scores were always obtained when the 5-phenyl-2-thiophenyl core was attached to the triazole. The selectivity of these compounds towards the nicotinic α4β2 and serotoninergic 5HT3 receptors was assessed and their brain penetration was quantified by the preparation and in vivo evaluation of two [18F] radiolabelled derivatives. It can be expected from our results that some of these compounds will be suitable for further developments and will have effects on cognitive disorders.

Solution-processable polyphenylphenyl dendron bearing molecules for highly efficient blue light-emitting diodes

(Chemical Equation Presented) Novel solution-processable blue light-emitting materials Blue A-D, bearing a polyphenylphenyl dendron, have been synthesized and characterized. The energy levels and band gaps can be facilely tuned by changing the central aro