106014-25-9

Basic information

• Product Name: Benzoic acid, 4-fluoro-2-formyl-, methyl ester
• CAS NO: 106014-25-9
• Molecular Formula: C9H7FO3
• Mol File: 106014-25-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-fluoro-2-formyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-fluoro-2-formyl-, methyl ester(106014-25-9)
• EPA Substance Registry System: Benzoic acid, 4-fluoro-2-formyl-, methyl ester(106014-25-9)

Safety Data

• Hazardous Substances Data: 106014-25-9(Hazardous Substances Data)

Upstream product

• 74-88-4 methyl iodide 
• 127510-96-7 2-cyano-4-fluorobenzoic acid methyl ester 
• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 700-85-6 5-fluoroisobenzofuran-1(3H)-one 
• 77-78-1 dimethyl sulfate 

Relevant articles and documents

Indium-Catalyzed C?F Bond Transformation through Oxymetalation/β-Fluorine Elimination to Access Fluorinated Isocoumarins

Fluorinated heterocycles have attracted much attention in the pharmaceutical and agrochemical industries. Many strategies have already been developed to achieve the synthesis of fluorinated heterocycles. Formidable challenges remain, however, in the synthesis of fluorinated isocoumarin derivatives that are among the most alluring structural motifs. Herein, the indium-catalyzed C?F bond transformation of 2-(2,2-difluorovinyl) benzoates is reported, which are readily accessible compounds, to give a diverse array of fluorinated isocoumarins. The present reaction proceeds smoothly using inexpensive reagents: a catalytic amount of indium salt in the presence of zinc salt. A theoretical calculation of potential energy profiles showed that the reaction consists of oxymetalation with the elimination of alkyl halide and the β-fluorine elimination.

Synthesis of chiral isoindolinones via asymmetric propargylation/lactamization cascade

A Zn-mediated propargylation/lactamization cascade reaction with chiral 2-formylbenzoate derived N-tert-butanesulfinyl imines was realized, which provided a practical and efficient method for the synthesis of chiral isoindolinones. High diastereoselectivities (up to 97:3 dr) and good reaction yields were observed for most examined cases.

1-carbalkoxyalkyl-3-aryloxy-4-(substituted-2'-carboxyphenyl)-azet-2-ones as plant growth regulators and herbicides

Compounds of the formula: STR1 wherein R1 is lower alkyl or benzyl; R2 is lower alkoxy, benzyloxy or the group STR2 where R3 is lower alkoxy; Ar is phenyl or phenyl substituted with 1 to 3 substituents independently selected from halogen, trihalomethyl, nitro, phenyl, lower alkoxy and lower alkyl; and X1 and X2 are independently hydrogen, halogen, lower alkoxy, or lower alkyl, or X1 and X2 taken together form an aromatic ring fused with the phenyl ring, provided that both X1 and X2 are not hydrogen show activity as plant growth regulators.