1006-41-3

Basic information

• Product Name: 2-Bromo-4-fluorobenzoic acid
• Synonyms: RARECHEM AL BO 1996;BUTTPARK 18\02-85;2-BROMO-4-FLUOROBENZOIC ACID;2-Bromo-4-Fluorobenzoic;2-Bromo-4-fluorobenzoicacid98%;2-bromo-4-fluorobenzioc acid;2-BroMo-4-fluorobenzoic Acid, 97+%;2-Bromofluorobenzoic Acid
• CAS NO: 1006-41-3
• Molecular Formula: C₇H₄BrFO₂
• Molecular Weight: 219.01
• EINECS: -0
• Product Categories: Fluorin-contained Benzoic acid series;FINE Chemical & INTERMEDIATES;blocks;Bromides;Carboxes;FluoroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Fluorobenzene;Acids & Esters;Bromine Compounds;Fluorine Compounds;C7;Carbonyl Compounds;Carboxylic Acids;Benzoic acid series;intermediate
• Mol File: 1006-41-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 172-176 °C(lit.)
• Boiling Point: 294.257 °C at 760 mmHg
• Flash Point: 131.762 °C
• Appearance: white fine powder
• Density: 1.7218 (rough estimate)
• Vapor Pressure: 0.000745mmHg at 25°C
• Refractive Index: 1.4240 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.79±0.10(Predicted)
• Water Solubility: Soluble in water and methanol.
• BRN: 2614292
• CAS DataBase Reference: 2-Bromo-4-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-fluorobenzoic acid(1006-41-3)
• EPA Substance Registry System: 2-Bromo-4-fluorobenzoic acid(1006-41-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1006-41-3(Hazardous Substances Data)

Usage

Chemical Properties

white fine powder

Uses

2-Bromo-4-fluorobenzoic acid is used in the synthesis of 3-fluoro-8-(methylthio)dibenzo[b,f]thiepin-10(11H)-one, 2-fluoro-8-(methylthio)dibenzo[b,f]thiepin-10(11H)-one, 2-((2-carboxy-5-fluorophenyl)amino)-3-methoxybenzoic acid and 2-bromo-4-fluorobenzamide. It is also used in the preparation of boron-containing anti-fungal agents, in the treatment of onychomycosis.

General Description

Amination of 2-bromo-4-fluorobenzoic acid with aniline is reported to yield N-phenyl-4-fluoro-anthranilic acid.

InChI:InChI=1/C7H4BrFO2/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3H,(H,10,11)/p-1

Upstream product

• 1422-53-3 2-bromo-4-fluorotoluene 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 456-22-4 4-Fluorobenzoic acid 
• 7745-91-7 3-bromo-4-methylaniline 

Downstream Products

• 141829-04-1 4-fluoro-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoic acid 
• 95383-36-1 2-bromo-4-fluorobenzoyl chloride 
• 410545-51-6 4-fluoro-2-(methylthio)benzoic acid 
• 653-92-9 methyl 2-bromo-4-fluorobenzoate 
• 446-32-2 4-fluoroanthranilic acid 
• 1017858-34-2 Tert-butyl 4-({[(2-bromo-4-fluorophenyl)amino]carbonyl}oxy)piperidine-1-carboxylate 
• 289038-14-8 2-bromo-4-fluorobenzylamine hydrochloride 
• 1293323-83-7 (2-bromo-4-fluorobenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester 
• 36282-26-5 2-bromo-4-fluorobenzonitrile 
• 1006-40-2 2-bromo-4-fluorobenzamide 
• 1376129-52-0 2-benzyl-5-fluoro-2,3-dihydro-1H-inden-1-one 
• 500779-09-9 2-(carboxymethyl)-4-fluorobenzoic acid 
• 56096-99-2 <2-(4-chlorophenylthio)-4-fluorophenyl>acetic acid 

Relevant articles and documents

Aerobic oxidation of aldehydes to carboxylic acids catalyzed by recyclable ag/c3 n4 catalyst

The oxidation of aldehydes is an efficient methodology for the synthesis of carboxylic acids. Herein we hope to report a simple, efficient and recyclable protocol for aerobic oxidation of aldehydes to carboxylic acid by using C3N4 supported silver nanoparticles (Ag/C3N4) as a catalyst in aqueous solution under mild conditions. Under standard conditions, the corresponding carboxylic acids can be obtained in good to excellent yields. In addition, Ag/C3N4 is convenient for recovery and could be reused three times with satisfactory yields.

Light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C-H bonds

Visible light-induced organic reactions are important chemical transformations in organic chemistry, and their efficiency highly depends on suitable photocatalysts. However, the commonly used photocatalysts are precious transition-metal complexes and elaborate organic dyes, which hamper large-scale production due to high cost. Here, for the first time, we report a novel strategy: light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C-H bonds, allowing high-value-added aromatic ketones and carboxylic acids to be easily prepared in high-to-excellent yields using readily available alkyl arenes, methyl arenes and aldehydes as materials. The mechanistic investigations showed that the treatment of inexpensive and readily available sodium trifluoromethanesulfinate with oxygen under irradiation of light could in situ form a pentacoordinate sulfide intermediate as an efficient photosensitizer. The method represents a highly efficient, economical and environmentally friendly strategy, and the light and oxygen-enabled sodium trifluoromethanesulfinate photocatalytic system represents a breakthrough in photochemistry. This journal is

Continuous synthesis method for substituted benzoic acid organic matter

The invention provides a continuous synthesis method for a substituted benzoic acid organic matter. The continuous synthesis method comprises the following steps: in the presence of a catalyst and anorganic solvent, continuously putting an organic matter of a formula (I) shown in the specification, and oxygen into a continuous reaction device, carrying out a continuous oxidation reaction so as toobtain the substituted benzoic acid organic matter, and continuously discharging the substituted benzoic acid organic matter, wherein the substituted benzoic acid organic matter is of a structure ofa formula (II) shown in the specification. Oxygen is a green reagent and is cheap and easy to obtain, a great amount of wastes are not generated after reactions are completed, and the system is easy to treat. Due to continuous reaction operation, the risk that the solvent has flash evaporation explosion because of high-concentration oxygen in in-batch reactions can be reduced. Under same oxidationconditions, due to a continuous preparation process, escape of oxygen can be reduced, the utilization rate of oxygen can be greatly increased, operation can be also simplified, the security of reactions can be improved, and the yield of the substituted benzoic acid organic matter can be increased.