1060171-73-4Relevant articles and documents
Design, synthesis, and primary activity assays of baicalein derivatives as cyclin-dependent kinase 1 inhibitors
Mou, Jiajia,Qiu, Shuang,Chen, Danghui,Deng, Yanru,Tekleab, Teka
, p. 639 - 654 (2021)
Malignant tumor is a disease with high mortality. Traditional treatment methods have many disadvantages, such as side-effects, drug resistance. Because cyclin-dependent kinase 1 (CDK1) plays an indispensable role in cell cycle regulation, it became an att
Baicalein derivative as well as preparation method and application thereof (by machine translation)
-
Paragraph 0123-0125; 0220, (2020/05/05)
The invention discloses a baicalein derivative, structure as shown in the specification : In-flight, R1 A hydrogen, alkyl, is substituted or unsubstituted aryl ;R. 2 The hydrogen, halogen, alkyl, alkoxy, may be substituted or unsubst
Design, synthesis, biological evaluation, and molecular docking of novel flavones as H3R inhibitors
Wen, Gang,Liu, Qian,Hu, Huabin,Wang, Dongmei,Wu, Song
, p. 580 - 589 (2017/09/14)
A series of novel flavone derivatives were designed, synthesized, and evaluated for their H3R inhibitory activity. The results showed that four compounds exhibited significant anti-H3R activity. Molecular docking experiments indicated that a salt bridge, hydrogen-bonding, and hydrophobic interactions all contributed to interactions between inhibitors and H3R.