106020-08-0Relevant articles and documents
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates
El-Messery, Shahenda M.,Hassan, Ghada S.,Nagi, Mahmoud N.,Habib, El-Sayed E.,Al-Rashood, Sarah T.,El-Subbagh, Hussein I.
, p. 4815 - 4823 (2016/09/13)
A new series of 2,3,6-substituted-quinazolin-4-ones was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor activities. Compounds 28 and 61 proved to be active DHFR inhibitors with IC500.02 and
Investigation into a By-product from the Reaction of 2-Amino-5-methylbenzoic Acid with Ammonium Thiocyanate
Kennewell, Peter D.,Scrowston, Richard M.,Shenouda, Ibrahim G.,Tully, W. Roger,Westwood, Robert
, p. 2001 - 2025 (2007/10/02)
One of the by-products from the reaction of 2-amino-5-methylbenzoic acid with ammonium thiocyanate is shown to be 2,3-dihydro-5-methyl-2-thioxo-3-p-tolylquinazolin-4(1H)-one (6).This reacts with hydrazine to give three products (21)-(23), which have been converted into tetrazolo- (27) and 1,2,4-triazolo-quinazolino-derivatives (20) and (30).The products from the reaction of o-aminoacetophenone with an aryl isothiocyanate are converted into a reactive 1-azabuta-1,3-diene intermediate (34), which undergoes a ? cycloaddition reaction with dimethyl acetylenedicarboxylate, followed by a retro-Diels-Alder reaction, to give dimethyl 4-methylquinoline-2,3-dicarboxylate.
