79714-12-8Relevant articles and documents
Regioselective synthesis and biological evaluation of: N -substituted 2-aminoquinazolin-4-ones
Liao, Zhen-Yuan,Yeh, Wen-Hsiung,Liao, Pen-Yuan,Liu, Yu-Ting,Chen, Ying-Cheng,Chen, Yi-Hung,Hsieh, Tsung-Han,Lin, Chia-Chi,Lu, Ming-Hsuan,Chen, Yi-Song,Hsu, Ming-Chih,Li, Tsai-Kun,Chien, Tun-Cheng
supporting information, p. 4482 - 4494 (2018/06/29)
The reaction of methyl anthranilates with N-arylcyanamides in the presence of p-TsOH in t-BuOH under reflux afforded predominantly 3-arylquinazolin-4-ones. In contrast, the reaction of the same reactants with TMSCl in t-BuOH at 60 °C followed by the Dimro
Investigation into a By-product from the Reaction of 2-Amino-5-methylbenzoic Acid with Ammonium Thiocyanate
Kennewell, Peter D.,Scrowston, Richard M.,Shenouda, Ibrahim G.,Tully, W. Roger,Westwood, Robert
, p. 2001 - 2025 (2007/10/02)
One of the by-products from the reaction of 2-amino-5-methylbenzoic acid with ammonium thiocyanate is shown to be 2,3-dihydro-5-methyl-2-thioxo-3-p-tolylquinazolin-4(1H)-one (6).This reacts with hydrazine to give three products (21)-(23), which have been converted into tetrazolo- (27) and 1,2,4-triazolo-quinazolino-derivatives (20) and (30).The products from the reaction of o-aminoacetophenone with an aryl isothiocyanate are converted into a reactive 1-azabuta-1,3-diene intermediate (34), which undergoes a ? cycloaddition reaction with dimethyl acetylenedicarboxylate, followed by a retro-Diels-Alder reaction, to give dimethyl 4-methylquinoline-2,3-dicarboxylate.
A NOVEL SYNTHESIS OF 2-SUBSTITUTED QUINAZOLIN-4(3H)-ONES
Svetlik, Jan
, p. 1281 - 1285 (2007/10/02)
Aromatic or mixed carbodiimides and ketenimines react with ethyl allophanate to give corresponding substituted quinazolin-4(3H)-ones.