106023-63-6

Basic information

• Product Name: 1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE
• Synonyms: 1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE;DIBOL
• CAS NO: 106023-63-6
• Molecular Formula: C₄H₈Br₂O
• Molecular Weight: 231.91
• Mol File: 106023-63-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 40-41 °C
• Boiling Point: 276.6±30.0 °C(Predicted)
• Appearance: /
• Density: 1.951±0.06 g/cm3(Predicted)
• PKA: 14.22±0.10(Predicted)
• CAS DataBase Reference: 1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE(106023-63-6)
• EPA Substance Registry System: 1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE(106023-63-6)

Safety Data

• Hazardous Substances Data: 106023-63-6(Hazardous Substances Data)

Usage

General Description

1-Bromo-2-bromomethyl-3-hydroxy-propane is a chemical compound with the molecular formula C3H7Br2O. It is a clear, colorless liquid that is commonly used as an intermediate in the production of pharmaceuticals and organic compounds. 1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE is known for its bromomethyl and hydroxy functional groups, which make it valuable in chemical synthesis. It is important to handle 1-bromo-2-bromomethyl-3-hydroxy-propane with caution, as it is considered harmful if swallowed, can cause skin and eye irritation, and may have adverse effects on aquatic life. Overall, this chemical is widely used in the production of various organic compounds and pharmaceuticals, and its properties make it a versatile and valuable intermediate in chemical synthesis.

Upstream product

• 41459-42-1 3-bromo-2-(bromomethyl)propionic acid 
• 22262-60-8 methyl 3-bromo-2-(bromomethyl)propionate 

Downstream Products

• 127542-22-7 3-bromo-2-(bromomethyl)propyl 6-O-acetyl-3-deoxy-3C-methyl-4-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-β-D-glucopyranoside 
• 127542-50-1 3-bromo-2-(bromomethyl)propyl 2,3,6-tri-O-benzoyl-4-O-<6-O-acetyl-2,3-di-O-benzoyl-4-O-(2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl)-β-D-galactopyranosyl>-β-D-glucopyranoside 

Relevant articles and documents

3-BROMO-2-BROMOMETHYLPROPYL GLYCOSIDES IN THE PREPARATION OF DOUBLE-CHAIN BIS-SULFIDE NEO-GLYCOLIPIDS

Boron trifluoride etherate-induced glycosilation of 3-bromo-2-bromomethylpropan-1-ol with sugar acetates gave the title glycosides of the following sugars of the D series: Glcp, Galp, GlcpA, GlcNPhthp, Xylp, β-Galp-(1->4)-Glcp, and α-Galp-(1->4)-Galp.Treatment of the fully acetylated glycosides with alkanethiols and cesium carbonate in N,N-dimethylformamide followed by deacetylation gave the corresponding bis-sulfide glycolipids.

Efficient synthesis of methanesulphonate-derived lipid chains for attachment of proteins to lipid membranes

We have developed an easy and flexible synthetic methodology to obtain lipid chains containing methanothiosulfonate terminal groups with the aim to attach them to natural proteins as functional groups. There are many proteins found in nature that are modified by lipids, and this is a key part of their function. For example, the prion protein is attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor, and this protein is thought to be the causative agent in diseases such as bovine spongiform encephalopathy (BSE; "mad cow disease") and the human equivalent Creutzfeldt-Jakob disease. However, production of large amounts of protein in bacteria results in proteins that lack these lipid modifications. The lipid chains containing methanothiosulfonate terminal groups that we have synthesized here can be attached to these proteins through the thiol contained in the side chain of the cysteine residue, which can be incorporated into the protein sequence at the desired position. Copyright Taylor & Francis Group, LLC.

PROPANOL DERIVATIVES

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