106023-63-6

Basic information

• Product Name: 1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE
• Synonyms: 1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE;DIBOL
• CAS NO: 106023-63-6
• Molecular Formula: C₄H₈Br₂O
• Molecular Weight: 231.91
• Mol File: 106023-63-6.mol

Chemical Properties

• Melting Point: 40-41 °C
• Boiling Point: 276.6±30.0 °C(Predicted)
• Appearance: /
• Density: 1.951±0.06 g/cm3(Predicted)
• PKA: 14.22±0.10(Predicted)
• CAS DataBase Reference: 1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE(106023-63-6)
• EPA Substance Registry System: 1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE(106023-63-6)

Safety Data

• Hazardous Substances Data: 106023-63-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE is used as an intermediate in the production of pharmaceuticals for its ability to facilitate the synthesis of various organic compounds.
Used in Organic Compounds Production:
1-BROMO-2-BROMOMETHYL-3-HYDROXY-PROPANE is used as a versatile intermediate in the synthesis of a range of organic compounds, leveraging its functional groups for chemical reactions.

Upstream product

• 22262-60-8 methyl 3-bromo-2-(bromomethyl)propionate 
• 41459-42-1 3-bromo-2-(bromomethyl)propionic acid 

Downstream Products

• 127542-22-7 3-bromo-2-(bromomethyl)propyl 6-O-acetyl-3-deoxy-3C-methyl-4-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-β-D-glucopyranoside 
• 127542-50-1 3-bromo-2-(bromomethyl)propyl 2,3,6-tri-O-benzoyl-4-O-<6-O-acetyl-2,3-di-O-benzoyl-4-O-(2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl)-β-D-galactopyranosyl>-β-D-glucopyranoside 

Relevant articles and documents

3-BROMO-2-BROMOMETHYLPROPYL GLYCOSIDES IN THE PREPARATION OF DOUBLE-CHAIN BIS-SULFIDE NEO-GLYCOLIPIDS

Boron trifluoride etherate-induced glycosilation of 3-bromo-2-bromomethylpropan-1-ol with sugar acetates gave the title glycosides of the following sugars of the D series: Glcp, Galp, GlcpA, GlcNPhthp, Xylp, β-Galp-(1->4)-Glcp, and α-Galp-(1->4)-Galp.Treatment of the fully acetylated glycosides with alkanethiols and cesium carbonate in N,N-dimethylformamide followed by deacetylation gave the corresponding bis-sulfide glycolipids.

ERK INHIBITOR AND USE THEREOF

Disclosed are a compound (as shown in formula I) as an extracellular signal-regulated kinase (ERK) inhibitor, a pharmaceutical composition thereof, a preparation method therefor, and use thereof in treating ERK-mediated diseases. Said compound plays a role by regulating a plurality of processes such as cell proliferation, apoptosis, migration and angiogenesis.

Efficient synthesis of methanesulphonate-derived lipid chains for attachment of proteins to lipid membranes

We have developed an easy and flexible synthetic methodology to obtain lipid chains containing methanothiosulfonate terminal groups with the aim to attach them to natural proteins as functional groups. There are many proteins found in nature that are modified by lipids, and this is a key part of their function. For example, the prion protein is attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor, and this protein is thought to be the causative agent in diseases such as bovine spongiform encephalopathy (BSE; "mad cow disease") and the human equivalent Creutzfeldt-Jakob disease. However, production of large amounts of protein in bacteria results in proteins that lack these lipid modifications. The lipid chains containing methanothiosulfonate terminal groups that we have synthesized here can be attached to these proteins through the thiol contained in the side chain of the cysteine residue, which can be incorporated into the protein sequence at the desired position. Copyright Taylor & Francis Group, LLC.

PROCESS FOR PRODUCTION OF FLUORINATED SULFONYL FLUORIDES

It is an object of the present invention to solve difficulty in production and to provide a process to obtain fluorinated sulfonyl fluoride compound having various molecular structures efficiently at a low cost. That is, the present invention provides a process which comprises reacting (FSO2-)nRA(-E-RB)m (1F) with fluorine in a liquid phase to form (FSO2-)nRAF(-EF-RBF)m (2), and decomposing this compound to obtain (FSO2-)nRAF(-EF1)m (3), provided that RA is a (n+m)valent organic group having at least two carbon atoms, RAF is a group having RA fluorinated, or the like, each of RB and RBF is a fluorinated monovalent organic group, or the like, E is -COOCH2- or the like, EF is -COOCF2- or the like, EF1 is -COF or the like, n is an integer of at least 2, and m is an integer of at least 1.

Propanol derivatives

Propanol derivatives of formula (I) wherein X is a leaving group; R1 is H or a protecting group; and R2 is H, and R3 is a group--CH2 Y wherein Y is a leaving group; or R2 and R3 together form =CH2. The propanol derivatives of the formula (I) are useful as multifunctional alkylating agents.

Glycosidic derivatives

O-glycosidic compounds useful for therapy or prophylaxis of a wide variety of diseases, for diagnostic use or as research chemicals. Another object of the present invention is to provide a method for preparing the O-glycosidic compounds.