10603-48-2

Basic information

• Product Name: 1-Benzyl-3-chloro-pyrrolidine
• Synonyms: 1-Benzyl-3-chloro-pyrrolidine
• CAS NO: 10603-48-2
• Molecular Formula: C₁₁H₁₄ClN
• Molecular Weight: 195.68856
• Mol File: 10603-48-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 132 °C(Press: 7 Torr)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• PKA: 7.69±0.40(Predicted)
• CAS DataBase Reference: 1-Benzyl-3-chloro-pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-3-chloro-pyrrolidine(10603-48-2)
• EPA Substance Registry System: 1-Benzyl-3-chloro-pyrrolidine(10603-48-2)

Safety Data

• Hazardous Substances Data: 10603-48-2(Hazardous Substances Data)

Usage

Chemical structure

Pyrrolidine derivative with a benzyl group and a chlorine atom attached to the pyrrolidine ring

Usage

Commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds

Applications

Potential applications in the field of medicinal chemistry, particularly in the development of new drugs

Safety

Important to handle with caution and follow appropriate safety protocols when working with it in a laboratory setting

Upstream product

• 5707-04-0 Phenylselenyl chloride 
• 17150-62-8 N-benzyl-3-butenylamine 
• 775-15-5 1-benzyl-3-pyrrolidinol 

Downstream Products

• 951027-20-6 1-(1-benzylpyrrolidin-3-yl)-1H-pyrrolo[2,3-b]pyridine 
• 10603-52-8 1-benzyl-pyrrolidine-3-carbonitrile 
• 3212-91-7 (1-benzyl-pyrrolidin-3-yl)-phenyl-pyridin-2-yl-acetonitrile 
• 96524-59-3 (1-Benzyl-pyrrolidin-3-yl)-{4-chloro-2-[(2-fluoro-phenyl)-imino-methyl]-phenyl}-amine 
• 96524-66-2 (1-Benzyl-pyrrolidin-3-yl)-(4-chloro-phenyl)-amine 

Relevant articles and documents

Preparation method of alkyl nitrile compound

The invention discloses a preparation method of an alkyl nitrile compound shown as formula I. The preparation method comprises the following step: in a solvent, in the presence of an additive and a catalyst, Zn (CN) 2 and an alkyl halide shown as formula II are subjected to a coupling reaction as shown in the specification to obtain the alkyl nitrile compound as shown in the formula I, wherein theadditive comprises an alkali, the catalyst comprises a nickel compound and a phosphine ligand; the nickel compound is one or more of zero-valent nickel, monovalent nickel salt and divalent nickel salt; when the nickel compound contains zero-valent nickel or divalent nickel salt, the catalyst further comprises a reducing agent. According to the preparation method disclosed by the invention, cyanation of an alkyl halide can be simply, conveniently and efficiently realized by using a cheap catalytic system, and the preparation method also has good functional group compatibility and substrate universality.

Stereocontrolled synthesis of 1,2-dialkyl-4-halopyrrolidines through PhSeX-induced cyclization of secondary homoallylamines

The selenium-induced cyclization of α-alkyl or α,α-dialkylhomoallyl-benzylamines 1 by use of PhSeX (X = Cl, Br, I; 1.5 equiv.) provided a mixture of (phenylselanylmethyl)azetidines 2 and (phenylselanyl)pyrrolidines 3.[1] When an excess of PhSeX (X = Cl, Br) was used, 4-halopyrrolidines 4 (X = Cl) or 5 (X = Br) were formed and isolated in very good yields. Mono- or dialkyl 4-halopyrrolidines 4 and 5 could also be obtained stereospecifically by SO2Cl2 or Br2 treatment of 4-(phenylselanylmethyl)azetidines 2, by way of the intermediate (halomethyl)azetidines 14 (X = Cl) or 15 (X = Br). When starting from 4-(phenylselanyl)pyrrolidines 3, monoalkylated 4-halopyrrolidines 4 or 5 could be obtained stereospecifically after decomposition of the unstable dihaloselenuranes 16 and 17. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.