10603-52-8

Usage

Uses

Used in Pharmaceutical Industry:
1-Benzyl-pyrrolidine-3-carbonitrile is used as a crucial intermediate in the synthesis of various pharmaceutical products for its role in creating the final drug compounds.
Used in Respiratory Treatments:
1-Benzyl-pyrrolidine-3-carbonitrile is used as a bronchodilator for treating respiratory conditions, as it helps in relaxing and opening air passages in the lungs, providing relief to patients suffering from such conditions.

InChI:InChI=1/C12H14N2/c13-8-12-6-7-14(10-12)9-11-4-2-1-3-5-11/h1-5,12H,6-7,9-10H2

Upstream product

• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 107-13-1 acrylonitrile 
• 10442-39-4 tetra-n-butylammonium cyanide 
• 104016-82-2 (3R)-1-benzyl-3-methanesulfonyloxy pyrrolidine 
• 10603-48-2 1-benzyl-3-chloropyrrolidine 
• 557-21-1 dicyanozinc 
• 557-21-1 zinc(II) cyanide 
• 775-15-5 1-benzyl-3-pyrrolidinol 
• 18471-40-4 1-Benzyl-3-aminopyrrolidine 
• 143-33-9 sodium cyanide 

Downstream Products

• 5747-92-2 1-benzyl-3-carboethoxypyrrolidine 
• 93138-61-5 C-(1-benzyl-pyrrolidin-3-yl)-methylamine 
• 96568-35-3 1-benzyl-3-(methylamino)pyrrolidine 
• 26803-22-5 (1-benzyl-pyrrolidin-3-yl)-(4-fluoro-phenyl)-methanone 
• 72925-15-6 3-ethoxycarbonyl-pyrrolidine 
• 1609735-07-0 1-benzyl-3-(quinazolin-4-yl)pyrrolidine-3-carbonitrile 
• 680223-81-8 (+/-)-3-(1-benzylpyrrolidin-3-yl)-5-methyl-2H-isoquinolin-1-one 

Relevant academic research and scientific papers

Tris(pentafluorophenyl)borane-catalyzed synthesis of N-benzyl pyrrolidines

1,3-Dipolar cycloaddition of in situ generated azomethine ylides to electron deficient olefins catalyzed tris(pentafluorophenyl)borane is described. Georg Thieme Verlag Stuttgart.

Nickel-Catalyzed Deaminative Cyanation: Nitriles and One-Carbon Homologation from Alkyl Amines

A nickel-catalyzed deaminative cyanation of Katritzky pyridinium salts has been developed. When it is coupled with formation of the pyridinium salt from primary amines, this method enables alkyl amines to be converted to alkyl nitriles. A less toxic cyanide reagent, Zn(CN)2, is utilized, and diverse functional groups and heterocycles are tolerated. The method also enables a one-carbon homologation of alkyl amines via reduction of the nitrile products, in addition to many other potential transformations of the versatile nitrile group.

Preparation method of alkyl nitrile compound

The invention discloses a preparation method of an alkyl nitrile compound shown as formula I. The preparation method comprises the following step: in a solvent, in the presence of an additive and a catalyst, Zn (CN) 2 and an alkyl halide shown as formula II are subjected to a coupling reaction as shown in the specification to obtain the alkyl nitrile compound as shown in the formula I, wherein theadditive comprises an alkali, the catalyst comprises a nickel compound and a phosphine ligand; the nickel compound is one or more of zero-valent nickel, monovalent nickel salt and divalent nickel salt; when the nickel compound contains zero-valent nickel or divalent nickel salt, the catalyst further comprises a reducing agent. According to the preparation method disclosed by the invention, cyanation of an alkyl halide can be simply, conveniently and efficiently realized by using a cheap catalytic system, and the preparation method also has good functional group compatibility and substrate universality.

Nickel-Catalyzed Cyanation of Unactivated Alkyl Chlorides or Bromides with Zn(CN)2

A nickel-catalyzed cyanation of unactivated secondary alkyl chlorides or bromides using less toxic Zn(CN)2 as the cyanide source has been developed. The reaction features the use of air-stable and inexpensive NiCl2·6H2O or Ni(acac)2 as the precatalysts and offers an efficient synthesis of a broad range of alkyl nitriles. Cyanation of primary alkyl chlorides or bromides was also achieved by reaction with Zn(CN)2 in the presence of n-Bu4NCl without the need of nickel catalyst.

BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS

The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1 ), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and diabetes.

Antibacterial compounds

Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.

Indole, azaindole and related heterocyclic pyrrolidine derivatives

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity

1-(4-PIPERIDINYL) BENZIMIDAZOLONES AS HISTAMINE H3 ANTAGONISTS

Disclosed are histamine H3 antagonists of the formula (I) wherein R1 is benzimidazolone derivative, M1 and M2 are optionally substituted carbon or nitrogen, R2 includes optionally substituted aryl or heteroaryl, and the remaining variables are as defined

5-HT3 receptor agonist, novel thiazole derivative and intermediate thereof

A 5-HT3 receptor against containing a thiazole derivative as the effective ingredient is provided and is represented by the Formula (I): STR1 wherein the A ring is substituted or unsubstituted and represents a benzene or a heterocyclic ring with one or two heteroatoms; one of L1 or L2 represents a single bond and the other is non-existent or represents an alkylene or alkenylene group; R represents: STR2