10603-52-8

Basic information

• Product Name: 1-BENZYL-PYRROLIDINE-3-CARBONITRILE
• Synonyms: 1-BENZYL-PYRROLIDINE-3-CARBONITRILE;1-BENZYL-3-CYANO-PYRROLIDINE
• CAS NO: 10603-52-8
• Molecular Formula: C₁₂H₁₄N₂
• Molecular Weight: 186.25
• Product Categories: pharmacetical
• Mol File: 10603-52-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 313.3 °C at 760 mmHg
• Flash Point: 132.8 °C
• Appearance: /
• Density: 1.08 g/cm³
• Vapor Pressure: 0.0005mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Room temperature.
• PKA: 7.26±0.40(Predicted)
• CAS DataBase Reference: 1-BENZYL-PYRROLIDINE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-PYRROLIDINE-3-CARBONITRILE(10603-52-8)
• EPA Substance Registry System: 1-BENZYL-PYRROLIDINE-3-CARBONITRILE(10603-52-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• RIDADR: UN 2811 6.1 / PGIII
• HazardClass: IRRITANT
• Hazardous Substances Data: 10603-52-8(Hazardous Substances Data)

Usage

General Description

1-Benzyl-pyrrolidine-3-carbonitrile, also scientifically known as C14H16N2, is a chemical compound that serves as a crucial intermediate in the synthesis of various pharmaceutical products. It has a molecular weight of 212.290 g/mol. 1-BENZYL-PYRROLIDINE-3-CARBONITRILE falls under the class of organic compounds known as benzene and substituted derivatives, characterized by their common feature, a benzene ring. Its physical state typically is a solid, it is typically stored in a cool and dry place to maintain its stability. Functionally, this chemical can act as a bronchodilator, thereby helping to treat respiratory conditions by relaxing and opening air passages in the lungs. Overall, this chemical is instrumental in the pharmaceutical industry, despite having little data on its physical properties and safety profile due to its primary role as an intermediate in synthesis reactions.

InChI:InChI=1/C12H14N2/c13-8-12-6-7-14(10-12)9-11-4-2-1-3-5-11/h1-5,12H,6-7,9-10H2

Upstream product

• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 107-13-1 acrylonitrile 
• 18471-40-4 1-Benzyl-3-aminopyrrolidine 
• 557-21-1 zinc(II) cyanide 
• 775-15-5 1-benzyl-3-pyrrolidinol 
• 10603-48-2 1-benzyl-3-chloropyrrolidine 
• 557-21-1 dicyanozinc 
• 10442-39-4 tetra-n-butylammonium cyanide 
• 104016-82-2 (3R)-1-benzyl-3-methanesulfonyloxy pyrrolidine 
• 143-33-9 sodium cyanide 

Downstream Products

• 26803-22-5 (1-benzyl-pyrrolidin-3-yl)-(4-fluoro-phenyl)-methanone 
• 72925-15-6 3-ethoxycarbonyl-pyrrolidine 
• 1609735-07-0 1-benzyl-3-(quinazolin-4-yl)pyrrolidine-3-carbonitrile 
• 680223-81-8 (+/-)-3-(1-benzylpyrrolidin-3-yl)-5-methyl-2H-isoquinolin-1-one 
• 96568-35-3 1-benzyl-3-(methylamino)pyrrolidine 
• 93138-61-5 C-(1-benzyl-pyrrolidin-3-yl)-methylamine 
• 5747-92-2 1-benzyl-3-carboethoxypyrrolidine 

Relevant articles and documents

Tris(pentafluorophenyl)borane-catalyzed synthesis of N-benzyl pyrrolidines

1,3-Dipolar cycloaddition of in situ generated azomethine ylides to electron deficient olefins catalyzed tris(pentafluorophenyl)borane is described. Georg Thieme Verlag Stuttgart.

Preparation method of alkyl nitrile compound

The invention discloses a preparation method of an alkyl nitrile compound shown as formula I. The preparation method comprises the following step: in a solvent, in the presence of an additive and a catalyst, Zn (CN) 2 and an alkyl halide shown as formula II are subjected to a coupling reaction as shown in the specification to obtain the alkyl nitrile compound as shown in the formula I, wherein theadditive comprises an alkali, the catalyst comprises a nickel compound and a phosphine ligand; the nickel compound is one or more of zero-valent nickel, monovalent nickel salt and divalent nickel salt; when the nickel compound contains zero-valent nickel or divalent nickel salt, the catalyst further comprises a reducing agent. According to the preparation method disclosed by the invention, cyanation of an alkyl halide can be simply, conveniently and efficiently realized by using a cheap catalytic system, and the preparation method also has good functional group compatibility and substrate universality.

BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS

The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1 ), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and diabetes.