106058-73-5

Upstream product

• 1677-46-9 4-hydroxy-1-methyl-2(1H)-quinolone 
• 538-51-2 benzylidene phenylamine 
• 1016-47-3 N-Acetyltryptamine 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 61469-95-2 1-methyl-1H-quinoline-2,4-dione 

Relevant academic research and scientific papers

Water-mediated, green, and efficient synthesis of bisquinolones under catalyst-free conditions

Water-mediated, green, and efficient synthesis involving condensation of 4-hydroxy-1-methylquinoline-2(1H)-one (3) with different aromatic and heterocyclic aldehydes (4a–n) leading to 3,3′-(arylmethylene)-bis-(4-hydroxy-1-methylquinolin-2(1H)-one) 5(a–n) under catalyst-free conditions is described. This reaction has an easy workup without using column chromatography and provides excellent yields of the products in shorter reaction times. It does not require any catalyst and uses water as the medium which is the greenest solvent. 3 required in this work was itself obtained by condensation of N-methylaniline (1) with malonic acid (2) in the presence of POCl3using a previously reported procedure.

Effect of heterocyclic ring system on formation of dimeric quinolones under catalyst-free conditions: a green approach

The intermediate-dependent green and efficient synthesis of dimeric quinolones 4a–l and 7a–l by the Knoevenagel condensation followed by Michael-type addition of 4-hydroxy-1-methylquinolin-2(1H)-one 1a, b to indole-3-aldehydes 2a–f and aromatic aldehydes

Synthesis of SF2809-V, chymase inhibitor, and its analogs by three component reaction: Model study for high throughput synthesis of a chymase inhibitor library

SF2809-V, chymase inhibitor, was synthesized by a three component reaction and its sixteen analogs were also synthesized to establish a method for preparation of a chymase inhibitor library.

Diversity-oriented Multicomponent Synthesis of Bisquinolones under Green Conditions

A diversity-oriented green and eco-friendly synthesis of bisquinolones have been developed by simply condensation of N-methylquinolone (1), with various benzaldehydes 2a–n and aniline (3) under catalyst-free conditions. An exciting feature of this communication is the product formation that depends on the intermediate (II) generated in the reaction mechanism.

DBU Acetate Mediated: One-pot Multi Component Syntheses of Dihydropyrano[3,2-c]quinolones

Three-component reaction involving condensation of 1-methylquinoline-2,4(1H,3H)-dione(1), aromatic aldehydes (2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h) and malononitrile/cyanoaceticester (3a, 3b) in{(1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium acetate)}[DBU][Ac] as ta

A highly efficient and green cascade synthesis of 3-methyl-substituted-4- hydroxy-1-methyl-quinolin-2(1H)-ones under solvent- and catalyst-free conditions

An expeditious and green protocol for the synthesis of 3,3′- methanediylbis(4-hydroxy-1-methylquinolin-2(1H)-one) (MDBHQ) derivatives and 3-((2-amino-6-oxocyclohex-1-enyl)methyl)-4-hydroxy-1-methylquinolin-2(1H)-one (AOCHQ) derivatives has been developed

One-step Synthesis of 3,3'-Benzylidene-bis(4-hydroxy-1-methyl/phenyl-2-quinolones)

A one-step synthesis of 3,3'-benzylidenebis(4-hydroxy-1-methyl/phenyl-2-quinolones) (5) involves the condensation of 4-hydroxy-1-methyl/phenyl-2-quinolone (1) with benzylideneanilines in acetic acid.The structure of the products have been established on the basis of spactral data.