106058-75-7

Upstream product

• 1677-46-9 4-hydroxy-1-methyl-2(1H)-quinolone 
• 123-11-5 4-methoxy-benzaldehyde 
• 136-95-8 2-amino-benzthiazole 
• 836-41-9 p-methoxybenzylidene-phenylamine 

Relevant academic research and scientific papers

A novel synthesis of 3-((benzo[d]thiazol-2-ylamino)(phenyl)methyl)-4-hydroxy-1-methylquinolin-2(1H)-one via consecutive C–C and C–N bond formation in water

Abstract: A simple, efficient, and eco-friendly protocol has been developed for the synthesis of novel 3-((benzo[d]thiazol-2-ylamino)(4-methoxyphenyl)methyl)-4-hydroxy-1-methylquinolin-2(1H)-one derivatives using a one-pot C–C and C–N bond forming strategy from the reaction of 4-hydroxy-1-methylquinolin-2(1H)-one, 2-aminobenzothiazole and aromatic aldehydes in aqueous solvent without using any metal catalyst. Several advantages of this protocol include its operational simplicity, short reaction time, mild reaction condition, efficient utilization of all the reactants, wide functional group tolerance, using water as an environmentally friendly solvent and non-chromatographic purification procedure. Graphic abstract: [Figure not available: see fulltext.].

Water-mediated, green, and efficient synthesis of bisquinolones under catalyst-free conditions

Water-mediated, green, and efficient synthesis involving condensation of 4-hydroxy-1-methylquinoline-2(1H)-one (3) with different aromatic and heterocyclic aldehydes (4a–n) leading to 3,3′-(arylmethylene)-bis-(4-hydroxy-1-methylquinolin-2(1H)-one) 5(a–n) under catalyst-free conditions is described. This reaction has an easy workup without using column chromatography and provides excellent yields of the products in shorter reaction times. It does not require any catalyst and uses water as the medium which is the greenest solvent. 3 required in this work was itself obtained by condensation of N-methylaniline (1) with malonic acid (2) in the presence of POCl3using a previously reported procedure.

Diversity-oriented Multicomponent Synthesis of Bisquinolones under Green Conditions

A diversity-oriented green and eco-friendly synthesis of bisquinolones have been developed by simply condensation of N-methylquinolone (1), with various benzaldehydes 2a–n and aniline (3) under catalyst-free conditions. An exciting feature of this communication is the product formation that depends on the intermediate (II) generated in the reaction mechanism.

Effect of heterocyclic ring system on formation of dimeric quinolones under catalyst-free conditions: a green approach

The intermediate-dependent green and efficient synthesis of dimeric quinolones 4a–l and 7a–l by the Knoevenagel condensation followed by Michael-type addition of 4-hydroxy-1-methylquinolin-2(1H)-one 1a, b to indole-3-aldehydes 2a–f and aromatic aldehydes

A highly efficient and green cascade synthesis of 3-methyl-substituted-4- hydroxy-1-methyl-quinolin-2(1H)-ones under solvent- and catalyst-free conditions

An expeditious and green protocol for the synthesis of 3,3′- methanediylbis(4-hydroxy-1-methylquinolin-2(1H)-one) (MDBHQ) derivatives and 3-((2-amino-6-oxocyclohex-1-enyl)methyl)-4-hydroxy-1-methylquinolin-2(1H)-one (AOCHQ) derivatives has been developed

One-step Synthesis of 3,3'-Benzylidene-bis(4-hydroxy-1-methyl/phenyl-2-quinolones)

A one-step synthesis of 3,3'-benzylidenebis(4-hydroxy-1-methyl/phenyl-2-quinolones) (5) involves the condensation of 4-hydroxy-1-methyl/phenyl-2-quinolone (1) with benzylideneanilines in acetic acid.The structure of the products have been established on the basis of spactral data.