1060684-38-9Relevant academic research and scientific papers
Development of a one-pot sequential Sonogashira coupling for the synthesis of benzofurans
Csékei, Márton,Novák, Zoltán,Kotschy, András
, p. 8992 - 8996 (2008/12/21)
An efficient one-pot protocol was developed for the construction of the benzofuran system from aryl halides and protected iodophenols using carbinol-based acetylene sources. The sequence includes alternating palladium-catalyzed Sonogashira couplings and deprotection steps concluded by a ring closure. The developed one-pot procedure was compared with the stepwise approach and its efficiency was also demonstrated by the total synthesis of vignafuran, a benzofuran natural product.
