787-64-4

Upstream product

• 271-89-6 1-benzofurane 
• 586-78-7 para-nitrophenyl bromide 
• 17490-72-1 2-(4-nitrobenzyloxy)benzaldehyde 
• 80645-51-8 p-nitrobenzoate de bromomethyl-2 phenyle 
• 98437-24-2 benzofuran-2-boronic acid 
• 100-01-6 4-nitro-aniline 
• 5421-45-4 2-methylphenyl 4-nitrobenzoate 
• 1123247-20-0 sodium (2-benzofuryl)dimethylsilanolate 
• 636-98-6 p-nitrobenzene iodide 
• 60981-57-9 (benzofuran-2-yl)trimethylsilane 
• 62-23-7 4-nitro-benzoic acid 
• 90-02-8 salicylaldehyde 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 15959-31-6 sodium 4-nitrobenzenesulfinate 

Downstream Products

• 782-18-3 4-(benzofuran-2-yl)benzenamine 
• 1373220-98-4 Br^(1-)*C₂₅H₁₉N₂O₂⁽¹⁺⁾ 
• 1373221-00-1 Br^(1-)*C₂₅H₁₉N₂O₃⁽¹⁺⁾ 
• 1373221-02-3 Br^(1-)*C₂₆H₂₁N₂O₃⁽¹⁺⁾ 
• 1373221-04-5 Br^(1-)*C₂₅H₁₈FN₂O₂⁽¹⁺⁾ 
• 1373221-06-7 Br^(1-)*C₂₅H₁₈BrN₂O₂⁽¹⁺⁾ 
• 1373221-10-3 Br^(1-)*C₃₁H₂₃N₂O₂⁽¹⁺⁾ 
• 1373220-83-7 C₁₇H₁₂N₂O 
• 1373220-86-0 Br^(1-)*C₂₄H₁₉N₂O⁽¹⁺⁾ 
• 1373220-89-3 Br^(1-)*C₂₄H₁₈BrN₂O⁽¹⁺⁾ 
• 1373220-92-8 Br^(1-)*C₂₀H₁₇N₂O⁽¹⁺⁾ 
• 1373220-95-1 C₂₁H₂₁N₂O⁽¹⁺⁾*I^(1-) 
• 101046-17-7 N-<4-(2-benzofuranyl)phenyl>maleamic acid 

Relevant academic research and scientific papers

Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y14R antagonists with anti-gout potential

The P2Y14 nucleotide receptor, a subtype of P2Y receptors, is implicated in many human inflammatory diseases. Based on the identification of favorable residues of two screening hits in the almost symmetrical P2Y14 binding domain, we

Room Temperature C-H Arylation of Benzofurans by Aryl Iodides

A robust method of room temperature direct arylation for benzofuran is reported. This discovery allows for mild arylation by commercially available aryl iodides with complete C-2 regioselectivity and tolerates a range of functional groups, including heat sensitive groups. Mechanistically, a Heck-type oxyarylation product from a direct arylation process is reported as a key piece of evidence for a carbopalladation intermediate.

GC/MSn analysis of the crude reaction mixtures from Friedel–Crafts acylation: Unambiguous identification and differentiation of 3-aroylbenzofurans from their 4- and 6-regioisomers

Rationale: 3-Aroylbenzofurans and their 2-nitrophenyl derivatives constitute fundamental intermediates for the synthesis of target compounds with pharmaceutical properties. However, their preparation via the Friedel–Crafts acylation of 2-phenylbenzofurans

Catalyst-Free Synthesis of Benzofuran Derivatives from Cascade Reactions between Nitroepoxides and Salicylaldehydes

Different benzofuran derivatives are synthesized via a catalyst-free reaction between nitroepoxides and salicylaldehydes. In the employed methodology, K2CO3 and DMF have been used at 110 °C, and the reactions were completed after 12 h in 33-84% yields. Th

Acid-promoted selective synthesis of trifluoromethylselenolated benzofurans with Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate

A Br?nsted acid-promoted trifluoromethylselenolation of benzofurans was disclosed by using Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate as a stable and easily prepared electrophilic trifluoromethylselenolating reagent. A wide range of SeCF3-substituted benzofuran derivatives were obtained in moderate to good yields with excellent regioselectivity. The tandem cyclization/trifluoromethylselenolation procedure of 1-methoxy-2-(arylethynyl)benzenes were also realized by engaging FeCl3 as the catalyst.

Direct (Hetero)arylation of Heteroarenes Catalyzed by Unsymmetrical Pd-PEPPSI-NHC Complexes under Mild Conditions

With the aim of developing a facile and efficient method to access structurally intriguing and valuable functionalized (hetero)aryls, two unsymmetrical Pd-PEPPSI-type NHC complexes (PEPPSI, pyridine-enhanced precatalyst preparation, stabilization, and initiation; NHC, N-heterocyclic carbene) were designed and synthesized to catalyze the direct arylation of heteroarenes with (hetero)aryl bromides. The results demonstrated that the utilization of this "unsymmetrical"strategy led to much higher efficiency in comparison to the commonly used C2-symmetric Pd-PEPPSI-type NHC complexes. Furthermore, a broad range of heteroaromatics and (hetero)aryl bromide partners with a wide variety of functional groups were all amenable to the developed protocol even at as low as 0.05 mol % catalyst loading and under aerobic conditions. More importantly, along with our study, we also found that the present protocol could provide expedient access to the gram-scale synthesis of the muscle relaxant drug dantrolene and conjugated mesopolymers.

Direct Arylations of Heteroarenes with Benzenesulfonyl Chlorides Using Pd/C Catalyst

The reactivity of heteroaromatics in direct arylation with benzenesulfonyl chlorides using 10 % Pd/C as catalyst was explored. With (benzo)thiophenes, (benzo)furans, pyrroles and selenophenes, high yields in arylated heteroarenes were obtained. These arylations were performed using only 5 mol-% Pd/C and Li2CO3 as inexpensive base. The regioselectivities are similar to those observed with homogeneous palladium catalysts. Better yields were obtained with electron-deficient benzenesulfonyl chlorides than with the electron-rich ones. Notably, useful substituents such as bromo or iodo on the benzenesulfonyl chloride were tolerated, as no cleavage of the C–Br or C–I bonds was observed under these conditions. The use of Pd/C presents several advantages compared to the previously employed homogeneous palladium catalysts, as it can be easily removed by filtration at the end of the reaction. The major side-products of the reaction are HBr associated to Li2CO3. Therefore, this new protocol affords a very attractive synthetic scheme in terms of cost, simplicity and low environmental impact for the access to arylated heteroaromatics.

σ-Bond initiated generation of aryl radicals from aryl diazonium salts

σ-Bond nucleophiles and molecular oxygen transform aryl diazonium salts into aryl radicals. Experimental and computational studies show that Hantzsch esters transfer hydride to aryl diazonium species, and that oxygen initiates radical fragmentation of the diazene intermediate to produce aryl radicals. The operational simplicity of this addition-fragmentation process for the generation of aryl radicals, by a polar-radical crossover mechanism, has been illustrated in a variety of bond-forming reactions.

New anti-cancer strategy to suppress colorectal cancer growth through inhibition of atg4b and lysosome function

Autophagy inhibition has been proposed to be a potential therapeutic strategy for cancer, however, few autophagy inhibitors have been developed. Recent studies have indicated that lysosome and autophagy related 4B cysteine peptidase (ATG4B) are two promis

Benzofuran small-molecule P2Y receptor inhibitor and preparation and application thereof

The invention discloses a benzofuran derivative shown in a formula (I) and a preparation method and application thereof. The experimental results show that the benzofuran derivative has good P2Y inhibitory activity and anti-inflammatory activity, and