1060692-20-7Relevant articles and documents
Design, Synthesis, and Activity Study of Cinnamic Acid Derivatives as Potent Antineuroinflammatory Agents
Huang, Shun,Liu, Wenfeng,Li, Yonglian,Zhang, Kun,Zheng, Xi,Wu, Hubing,Tang, Ganghua
, p. 419 - 429 (2021/02/01)
Neuroinflammatory cytokines are promising therapeutic targets for the treatment of Alzheimer's disease. Herein, we described our efforts toward the investigation of cinnamic acid derivatives as antineuroinflammatory agents. Intensive structural modificati
Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold
Tu, GuoGang,Li, ShaoHua,Huang, HuiMing,Li, Gang,Xiong, Fang,Mai, Xi,Zhu, HuaWei,Kuang, BinHai,Xu, Wen Fang
, p. 6663 - 6668 (2008/12/22)
The aminopeptidase N (APN/CD13), overexpressed in tumor cells, plays a critical role in angiogenesis. In this study, we report the synthesis and in vitro enzyme inhibition assay of 1,3,4-thiadiazole scaffold compounds. These new compounds have potent inhi