1060754-53-1

Upstream product

• 2448-45-5 Cbz-D-Phe 
• 13081-32-8 D-leucine tert-butyl ester hydrochloride 
• 501-53-1 benzyl chloroformate 
• 63060-94-6 D-phenylalanine ethyl ester hydrochloride 
• 42998-44-7 rac-N-benzyloxycarbonyl-phenylalanine ethyl ester 

Downstream Products

• 182966-22-9 (R)-2-[3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-2-oxo-pentanoylamino]-4-methyl-pentanoic acid tert-butyl ester 

Relevant academic research and scientific papers

Poststatin, a new inhibitor of prolyl endopeptidase. V. Endopeptidase inhibitory activity of poststatin analogues

Thirty analogues of poststatin were synthesized, and their inhibitory activities against prolyl endopeptidase, human leukocyte elastase and cathepsin B were measured. The α-ketone was essential and the S configuration was preferable to the R configuration in the β-substituted-β-amino-α-oxopropionic acid moiety of poststatin analogues for endopeptidase inhibitory activity. The analogue in which the D-leucine residue of poststatin was replaced by L-leucine showed strong inhibitory activity to cathepsin B. Introduction of an aromatic group into the P4 position and proline into the P2 position increased inhibitory activity to elastase. Benzyloxycarbonyl-L-homophenylalanyl-(RS)-3-amino-2-oxovaleryl-D- leucyl-L-valine was about 6 times more active to prolyl endopeptidase than natural poststatin.